低血清胆碱和高血清甜菜碱水平与纽芬兰人群代谢综合征的有利成分相关。

Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population.

机构信息

College of Life Sciences, Qingdao University, No.308,Ningxia Road, Qingdao, Shandong, China.

Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John's, NL, Canada.

出版信息

J Diabetes Complications. 2019 Oct;33(10):107398. doi: 10.1016/j.jdiacomp.2019.06.003. Epub 2019 Jun 20.

DOI:10.1016/j.jdiacomp.2019.06.003

PMID:31320248

Abstract

BACKGROUND

We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland.

METHODS

1081 adults were selected from the CODING study. Serum choline and betaine levels were measured. Major confounding factors were controlled in all analyses.

RESULTS

Partial correlation and linear regression analysis showed that serum choline levels were positively associated with systolic blood pressure (r: 0.124), serum TG levels (r: 0.132) and negatively correlated with serum glucose levels (r: -0.121) in males (p < 0.01 for all). In females, serum choline levels were positively correlated with serum TG, TC and HDL levels (r: 0.104 to 0.148, p < 0.05 for all). Serum betaine levels were negatively associated with serum TG, TC, LDL and insulin levels, and with atherogenic index and HOMA-IR index in males (r: -0.081 to -0.179, p < 0.05 for all). In females, serum betaine levels were negatively associated with serum TG, hsCRP and insulin levels, and with HOMA-IR index (r: -0.092 to -0.213, p < 0.05 for all). Moreover, subjects with serum choline levels in the highest tertile showed highest serum TG levels and systolic blood pressure in males, and highest serum lipids levels in females. Subjects with the highest serum betaine levels had the lowest serum lipids levels, atherogenic index, IR severity in males, and the lowest serum TG and hsCRP levels, and IR severity in females.

CONCLUSION

Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in general adults.

摘要

背景

我们调查了血清胆碱和甜菜碱水平与纽芬兰省普通人群代谢综合征相关指标的关系。

方法

从 CODING 研究中选择了 1081 名成年人。测量了血清胆碱和甜菜碱水平。在所有分析中均控制了主要混杂因素。

结果

偏相关和线性回归分析表明，男性血清胆碱水平与收缩压（r：0.124）、血清 TG 水平（r：0.132）呈正相关，与血清葡萄糖水平（r：-0.121）呈负相关（p均<0.01）。在女性中，血清胆碱水平与血清 TG、TC 和 HDL 水平呈正相关（r：0.104 至 0.148，p均<0.05）。血清甜菜碱水平与男性血清 TG、TC、LDL 和胰岛素水平以及致动脉粥样硬化指数和 HOMA-IR 指数呈负相关（r：-0.081 至-0.179，p均<0.05）。在女性中，血清甜菜碱水平与血清 TG、hsCRP 和胰岛素水平以及 HOMA-IR 指数呈负相关（r：-0.092 至-0.213，p均<0.05）。此外，男性血清胆碱水平最高三分位的受试者血清 TG 水平和收缩压最高，女性血清脂质水平最高。血清甜菜碱水平最高的受试者血清脂质水平、致动脉粥样硬化指数、IR 严重程度最低，男性血清 TG 和 hsCRP 水平及 IR 严重程度最低，女性。