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阿达木单抗成功治疗多发性顽固性坏疽性脓皮病面部病变

Multiple Facial Lesions of Recalcitrant Pyoderma Gangrenosum Successfully Treated with Adalimumab.

作者信息

Kleinfelder Raymond E, Hin Nady, Cubelli Stefanie, Snyder Allan, Kerdel Francisco, Glick Brad

机构信息

Drs. Kleinfelder and Hin are with the Dermatology Residency Program at the LECOMT/Larkin Community Hospital, Palm Springs Campus, in Hialeah, Florida.

Dr. Cubelli is with St. John's Episcopal Hospital in Far Rockaway, New York.

出版信息

J Clin Aesthet Dermatol. 2019 May;12(5):28-32. Epub 2019 May 1.

PMID:31320974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6561708/
Abstract

Pyoderma gangrenosum (PG) is a rare, ulcerative, inflammatory skin disease that most commonly presents on the lower legs. Development of PG on the head and neck is exceedingly rare. We present the case of a 52-year-old man with no known history of underlying systemic disease who developed multiple facial lesions of PG that were refractory to both standard and alternative treatment modalities. Clearance of disease was ultimately achieved using adalimumab.

摘要

坏疽性脓皮病(PG)是一种罕见的溃疡性炎症性皮肤病,最常出现在小腿。头颈部发生PG极为罕见。我们报告一例52岁男性患者,无已知潜在系统性疾病史,其面部出现多处PG皮损,对标准和替代治疗方式均无效。最终使用阿达木单抗实现了疾病清除。

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本文引用的文献

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Biologic and small-molecule medications in the management of pyoderma gangrenosum.用于坏疽性脓皮病治疗的生物制剂和小分子药物。
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The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum.年龄与坏疽性脓皮病临床表现和合并症的关系。
JAMA Dermatol. 2018 Apr 1;154(4):409-413. doi: 10.1001/jamadermatol.2017.5978.
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Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report.使用富血小板纤维蛋白治疗面部坏疽性脓皮病:一份技术报告。
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Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis.高压氧疗法治疗与溃疡性结肠炎相关的坏疽性脓皮病。
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Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies.经典型溃疡性坏疽性脓皮病是一种靶向毛囊附属器结构的T细胞介导性疾病:基于分子和临床病理研究的假说
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Treatment of severe recalcitrant pyoderma gangrenosum with ustekinumab.用优特克单抗治疗重度顽固性坏疽性脓皮病。
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Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum.溃疡性结肠炎相关性坏疽性脓皮病与特发性坏疽性脓皮病的临床特征比较。
Chin Med J (Engl). 2017 Nov 20;130(22):2674-2679. doi: 10.4103/0366-6999.218004.
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Curr Probl Dermatol. 2018;53:49-63. doi: 10.1159/000479475. Epub 2017 Nov 7.
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The safety of treatments used in pyoderma gangrenosum.坏疽性脓皮病治疗方法的安全性。
Expert Opin Drug Saf. 2018 Jan;17(1):55-61. doi: 10.1080/14740338.2018.1396316. Epub 2017 Oct 27.
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Australas J Dermatol. 2017 Nov;58(4):e270-e271. doi: 10.1111/ajd.12545. Epub 2017 Jun 28.