Sharma Shilpi, Mathur Deepak K, Paliwal Vijay, Bhargava Puneet
All authors are with the Department of Dermatology, Venereology, and Leprology at SMS Medical College and Attached Hospitals in Jaipur, India.
J Clin Aesthet Dermatol. 2019 May;12(5):34-38. Epub 2019 May 1.
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous units and has been associated with hyperandrogenism, which, in women, is most commonly caused by polycystic ovary syndrome (PCOS). Metformin treatment can correct ovarian and functional adrenal hyperandrogenism in adolescents with PCOS. We evaluated the efficacy of metformin therapy in women with acne and PCOS in terms of acne load. This was a hospital-based, interventional, longitudinal study that included 40 female patients with acne and PCOS diagnosed using the Rotterdam criteria. Hormonal assay, including serum levels of testosterone, dehydroepiandrosterone sulphate, luteinizing hormone, follicle-stimulating hormone, prolactin, and blood sugar, was conducted on the third or fourth day of the menstrual cycle in a fasted state. An abdominal ultrasound was performed on the ninth day of menstrual cycle to diagnose PCOS. Baseline acne severity was assessed as per the Definition Severity Index. Metformin 500mg was given to all selected patients three times a day for eight weeks. Patient follow-up and acne severity reassessment was conducted at Weeks 3 and 6. At Week 8, all work-ups were repeated. Intention-to-treat analysis was done. Wilcoxin signed-rank sum test was used to identify significance in acne severity. Metformin treatment significantly reduced acne severity in patients with PCOS (<0.001). Metformin reduces ovarian hyperandrogenism, leading to clinical improvement of acne in women with PCOS.
寻常痤疮是一种毛囊皮脂腺单位的慢性炎症性疾病，与雄激素过多有关，在女性中，最常见的原因是多囊卵巢综合征（PCOS）。二甲双胍治疗可纠正PCOS青少年的卵巢和功能性肾上腺雄激素过多。我们从痤疮负荷方面评估了二甲双胍治疗对患有痤疮和PCOS的女性的疗效。这是一项基于医院的干预性纵向研究，纳入了40例根据鹿特丹标准诊断为痤疮和PCOS的女性患者。在月经周期的第三天或第四天空腹状态下进行激素检测，包括血清睾酮、硫酸脱氢表雄酮、黄体生成素、卵泡刺激素、催乳素和血糖水平。在月经周期的第九天进行腹部超声检查以诊断PCOS。根据定义严重程度指数评估基线痤疮严重程度。给所有入选患者每天三次服用500mg二甲双胍，持续八周。在第3周和第6周对患者进行随访并重新评估痤疮严重程度。在第8周，重复所有检查。进行意向性分析。采用Wilcoxin符号秩和检验来确定痤疮严重程度的显著性。二甲双胍治疗显著降低了PCOS患者的痤疮严重程度（<0.001）。二甲双胍可降低卵巢雄激素过多，从而使PCOS女性的痤疮得到临床改善。
