Department of Parasitology and Entomology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Infect Disord Drug Targets. 2020;20(5):620-650. doi: 10.2174/1871526519666190716095849.
Recently, herbal medicine has received much attention in the literature. Several essential oils or plant extracts have been found to have anti-Acanthamoeba properties against trophozoites and cysts of Acanthamoeba spp.
The aim of this systematic review is to introduce anti-Acanthamoeba properties of some essential oils or plant extracts; perhaps the results of this research will be used to prevent and treat infectious diseases.
All published papers in English and Persian databases were systematically searched for some specific keywords to find articles that have influenced plant compounds on Acanthamoeba up to April 2018. Articles related to the subject were selected and studied.
A total of 51 articles including 136 experiments (128 in vitro and 8 in vivo) between 1999 and 2018, met our eligibility criteria. Totally, 110 species of plants belonging to 34 families, mainly Lamiaceae (15 plant species) and Asteraceae (13 plant species) were studied against trophozoites and cysts of Acanthamoba in in vitro and in vivo. Most of the plant's species were Citrus (6 species), Allium (5 species), Peucedanum, Piper, Lippia, and Olive (4 species). The most frequently used parts were leaves, aerial parts, flowers, bark, rhizomes, and seeds.
Recent studies have shown that many natural compounds have high anti-parasitic properties and low toxicity. Our research team hopes that the information provided in present systematic review can improve new experimental and clinical trials and herbal combination therapy. Further studies are needed to understand the molecular mechanisms in the anti-amoebic reactions of plant species and ocular toxicity of extracts in animal models.
最近，草药在文献中受到了广泛关注。已经发现几种精油或植物提取物对棘阿米巴属滋养体和包囊具有抗阿米巴作用。
本系统评价旨在介绍一些精油或植物提取物的抗棘阿米巴特性；也许这项研究的结果将被用于预防和治疗传染病。
系统检索了英语和波斯语数据库中所有已发表的论文，使用特定的关键词搜索有关植物化合物对棘阿米巴影响的文章，截至 2018 年 4 月。选择并研究了与主题相关的文章。
共纳入 51 篇文章，包括 1999 年至 2018 年的 136 项实验（128 项体外实验和 8 项体内实验），这些实验符合我们的入选标准。共有 110 种植物（隶属于 34 个科），主要为唇形科（15 种植物）和菊科（13 种植物），用于体外和体内研究棘阿米巴滋养体和包囊。大多数植物的种类为柑橘（6 种）、葱属（5 种）、细叶远志、胡椒、香蜂草和橄榄（各 4 种）。最常使用的部分是叶子、地上部分、花、树皮、根茎和种子。
最近的研究表明，许多天然化合物具有较高的抗寄生虫特性和较低的毒性。我们的研究团队希望本系统评价中提供的信息能够改进新的实验和临床试验以及草药联合治疗。需要进一步的研究来了解植物物种抗阿米巴反应的分子机制以及提取物在动物模型中的眼毒性。
