Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Batterjee Medical College for Sciences and Technology, Jeddah, Saudi Arabia.
Cancer Biomark. 2019;25(4):333-339. doi: 10.3233/CBM-190164.
E-cadherin and Fascin are adhesive proteins that are expressed in many tumors. It was supposed that loss of expression of these proteins is associated with increased aggressiveness of the tumor. Whether spinal and intracranial meningiomas express adhesion proteins in different rates is not yet known.
We aimed to investigate the expression of E-cadherin and Fascin in a large number of meningioma specimens and determine if clinical and prognostic significance existsMETHODS: One hundred and thirty-four spinal and intracranial meningioma samples were collected. Manual TMA blocks were constructed and immunohistochemistry for E-cadherin and Fascin was done. Focal or diffuse staining was considered positive.
Intracranial meningioma occurred in significantly younger age than spinal ones. Most of spinal meningiomas were of transitional histology. E-cadherin was expressed in 38.8% of cases. Spinal meningiomas showed statistically significant negative expression of E-cadherin than intracranial tumors. All atypical meningiomas showed negative E-cadherin expression. Fascin was expressed in 9% of cases with significant expression in atypical cases.
Aggressive behavior of meningioma could be explained in part by loss of E-cadherin and overexpression of Fascin especially in spinal meningiomas. Further studies are suggested to explore the biological aspects of spinal and intracranial meningiomas for constructing tailored targeted therapies.
E-钙黏蛋白和 Fascin 是在许多肿瘤中表达的黏附蛋白。据推测，这些蛋白表达的丧失与肿瘤侵袭性的增加有关。脊髓和颅内脑膜瘤的黏附蛋白表达率是否不同尚不清楚。
我们旨在研究大量脑膜瘤标本中 E-钙黏蛋白和 Fascin 的表达情况，并确定其是否具有临床和预后意义。
收集了 134 例脊髓和颅内脑膜瘤样本。构建手动 TMA 块，并进行 E-钙黏蛋白和 Fascin 的免疫组织化学染色。局灶性或弥漫性染色被认为是阳性的。
颅内脑膜瘤的发病年龄明显低于脊髓脑膜瘤。大多数脊髓脑膜瘤为过渡性组织学。38.8%的病例表达 E-钙黏蛋白。与颅内肿瘤相比，脊髓脑膜瘤的 E-钙黏蛋白表达呈统计学显著阴性。所有非典型脑膜瘤均表现为 E-钙黏蛋白表达阴性。 Fascin 在 9%的病例中表达，在非典型病例中表达显著。
脑膜瘤的侵袭性行为部分可以用 E-钙黏蛋白的缺失和 Fascin 的过度表达来解释，尤其是在脊髓脑膜瘤中。建议进一步研究以探索脊髓和颅内脑膜瘤的生物学方面，为构建针对性靶向治疗提供依据。
