Saito Ryo, Chambers James K, Uchida Kazuyuki
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
J Vet Med Sci. 2025 Jul 1;87(7):747-751. doi: 10.1292/jvms.25-0082. Epub 2025 May 14.
Peripheral nerve sheath tumors (PNSTs) and meningiomas in feline spinal canal are sometimes difficult to differentiate solely on the basis of histopathology. In this study, immunohistochemical markers for differentiating PNSTs from meningiomas were investigated. In the control group, non-spinal PNSTs were immunoreactive for S100 and GFAP but not for E-cadherin, whereas intracranial meningiomas were immunoreactive for E-cadherin but not for S100 and GFAP. In the spinal tumor group, 2/7 cases were immunoreactive for S100 and GFAP but not for E-cadherin and were considered PNSTs. In addition, 5/7 cases were immunoreactive for E-cadherin and not for S100 and GFAP and were considered meningiomas. Immunohistochemistry for S100, GFAP and E-cadherin may aid in the differential diagnosis of feline spinal PNSTs and meningiomas.
猫椎管内的周围神经鞘瘤（PNSTs）和脑膜瘤有时仅根据组织病理学难以区分。在本研究中，对用于区分PNSTs和脑膜瘤的免疫组化标志物进行了研究。在对照组中，非脊髓性PNSTs对S100和GFAP呈免疫反应，但对E-钙黏蛋白无反应，而颅内脑膜瘤对E-钙黏蛋白呈免疫反应，但对S100和GFAP无反应。在脊髓肿瘤组中，2/7例对S100和GFAP呈免疫反应，但对E-钙黏蛋白无反应，被认为是PNSTs。此外，5/7例对E-钙黏蛋白呈免疫反应，而对S100和GFAP无反应，被认为是脑膜瘤。S100、GFAP和E-钙黏蛋白的免疫组化可能有助于猫脊髓PNSTs和脑膜瘤的鉴别诊断。
