Department of Medical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, People's Republic of China.
J Alzheimers Dis. 2019;71(1):97-108. doi: 10.3233/JAD-190324.
Vascular dementia (VaD) is caused by chronic decreases in brain blood flow and accounts for 15-20% of dementia cases worldwide. In contrast to Alzheimer's disease (AD), no effective drug treatments are currently available for VaD. Previous studies have suggested that oxidative stress and neuroinflammation in the brain play important roles in the pathogenesis of VaD. Honokiol (HKL) is a well-known bioactive and nutraceutical compound that can act as an antioxidant and anti-inflammatory molecule. HKL can protect against memory impairments in AD mouse models. In this study, we explored whether the application of HKL was also protective against the insult of chronic cerebral hypoperfusion (CCH) in rats. We found that HKL supplementation prevented the memory impairments in the inhibitory avoidance step-down and Morris water maze tasks in CCH rats. HKL also suppressed the levels of oxidative stress and inflammation in CCH rats. Moreover, HKL prevented dendritic spines abnormalities in CCH rats. We also found that HKL inhibited the activity of GSK-3β, which may be critical for the neuroprotective activity of HKL. Thus, our study demonstrated the protective role of HKL in VaD.
血管性痴呆（VaD）是由慢性脑血流减少引起的，占全球痴呆病例的 15-20%。与阿尔茨海默病（AD）不同，目前尚无有效的药物治疗 VaD。先前的研究表明，大脑中的氧化应激和神经炎症在 VaD 的发病机制中起重要作用。厚朴酚（HKL）是一种众所周知的生物活性和营养化合物，可作为抗氧化剂和抗炎分子。HKL 可预防 AD 小鼠模型中的记忆障碍。在这项研究中，我们探讨了 HKL 的应用是否也能防止大鼠慢性脑低灌注（CCH）的损伤。我们发现 HKL 补充剂可预防 CCH 大鼠在抑制回避跳下和 Morris 水迷宫任务中的记忆障碍。HKL 还抑制了 CCH 大鼠的氧化应激和炎症水平。此外，HKL 防止了 CCH 大鼠树突棘异常。我们还发现 HKL 抑制了 GSK-3β的活性，这可能对 HKL 的神经保护活性至关重要。因此，我们的研究表明 HKL 在 VaD 中的保护作用。
