Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-69004 Lyon, France.
Service de Biostatistique, Hospices Civils de Lyon & Laboratoire Biostatistique-Santé, UMR CNRS 5558, LBBE, Université Claude Bernard Lyon 1, F-69424 Lyon, France.
Autoimmun Rev. 2019 Sep;18(9):102351. doi: 10.1016/j.autrev.2019.102351. Epub 2019 Jul 16.
Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic but about 60 causes of uveitis have been described. Our aim was to analyze the clinical patterns and etiologies of uveitis in a tertiary referral center.
The records of 912 consecutive patients referred to the department of internal medicine (Lyon University Hospital, Lyon, France) for the diagnostic work-up of uveitis were examined. Demographic, clinical, anatomical, and etiological features of uveitis were analyzed.
The mean age at onset was 48.8 years; 59.8% of the patients were women and 78.2% were Caucasians. Anterior uveitis was the most common type of uveitis (40.6%), followed by panuveitis (31.7%), posterior (18.75%) and intermediate uveitis (9%). 46.9% of the patients had idiopathic uveitis. The most common etiologies were systemic diseases (37.3%), such as sarcoidosis (17.1%), HLA-B27-related uveitis and/or spondyloarthritis (12.5%), and tuberculosis (7.5%).
We describe one of the largest cohorts of consecutive uveitis patients referred to a department of internal medicine. The high percentage of uveitis associated with underlying (systemic) diseases highlights the need for a multidisciplinary approach, in order to reduce the diagnostic delay.
葡萄膜炎是风湿免疫科最常见的眼科表现。这种疾病通常是特发性的，但已描述了约 60 种葡萄膜炎的病因。我们的目的是分析三级转诊中心葡萄膜炎的临床类型和病因。
对 912 例连续转诊至法国里昂大学医院内科部门进行葡萄膜炎诊断评估的患者记录进行了检查。分析了葡萄膜炎的人口统计学、临床、解剖和病因特征。
发病的平均年龄为 48.8 岁；59.8%的患者为女性，78.2%为白种人。前葡萄膜炎是最常见的葡萄膜炎类型（40.6%），其次是全葡萄膜炎（31.7%）、后葡萄膜炎（18.75%）和中间葡萄膜炎（9%）。46.9%的患者为特发性葡萄膜炎。最常见的病因是系统性疾病（37.3%），如结节病（17.1%）、HLA-B27 相关葡萄膜炎和/或脊柱关节炎（12.5%）和结核病（7.5%）。
我们描述了内科连续转诊的最大葡萄膜炎患者队列之一。与潜在（系统性）疾病相关的葡萄膜炎比例很高，这突出表明需要多学科方法，以减少诊断延迟。
