Grumet P, Kerever S, Gilbert T, Kodjikian L, Gerfaud-Valentin M, De Parisot A, Jamilloux Y, Sève P
Servicede Médecine Interne, Hôpital de la Croix-Rousse, Hospic es Civils de Lyon, Université Claude Bernard-Lyon 1, 103 grande rue de la Croix-Rousse, 69318, Lyon Cedex 04, France.
Service d'Anesthésie-Réanimation, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1971-1979. doi: 10.1007/s00417-019-04411-1. Epub 2019 Jul 16.
To describe the characteristics of de novo uveitis in patients ≥ 60 years old.
Retrospective review of patients with uveitis followed in our tertiary center over a 14-year period. Patients aged 60-70 years and patients aged > 70 years were compared.
A total of 283/1044 (27.1%) patients with uveitis were ≥ 60 years of age. Idiopathic uveitis (36.1%) and sarcoidosis (31.5%) were the most frequent etiologies. Sarcoidosis was significantly more frequent (31.5% vs. 13.7%, p < 0.0001) after the age of 60 years. Intraocular lymphoma (5.0% vs. 1.1%) and herpes virus infection (5.0% vs. 0.9%) were also more common in this age group, unlike HLA B27-related uveitis and spondyloarthritis (4.6% vs. 14.9%). Pure ophthalmologic entities: birdshot retinochoroidopathy (2.8%) or Fuchs uveitis (0.4%), were rare in patients ≥ 60 years of age and Posner Scholssman, Pars planitis, White dots syndrome, Behçet's disease, and Multiple Sclerosis were never reported. In patients > 70 years old, idiopathic uveitis (41.1% vs. 31.7%) and presumed sarcoidosis (56.5% vs. 25.6%) were more frequent than in the 60-70-year age group.
In our center, sarcoidosis is the leading cause of non-idiopathic uveitis in older patients. Idiopathic uveitis and other entities account for less than two-thirds of cases. Ophthalmologic entities are rare after 60 years of age. We also report for the first time the characteristics of uveitis after 70 years of age.
描述60岁及以上患者的初发性葡萄膜炎的特征。
回顾性分析在我们三级中心随访14年的葡萄膜炎患者。比较60至70岁的患者和70岁以上的患者。
共有283/1044（27.1%）例葡萄膜炎患者年龄≥60岁。特发性葡萄膜炎（36.1%）和结节病（31.5%）是最常见的病因。60岁以后结节病明显更常见（31.5%对13.7%，p<0.0001）。眼内淋巴瘤（5.0%对1.1%）和疱疹病毒感染（5.0%对0.9%）在该年龄组也更常见，这与HLA B27相关葡萄膜炎和脊柱关节炎（4.6%对14.9%）不同。单纯眼科疾病：鸟枪弹样视网膜脉络膜病变（2.8%）或富克斯葡萄膜炎（0.4%）在60岁及以上患者中很少见，且从未报告过波斯纳-施洛斯曼综合征、周边部葡萄膜炎、白点综合征、白塞病和多发性硬化症。在70岁以上的患者中，特发性葡萄膜炎（41.1%对31.7%）和疑似结节病（56.5%对25.6%）比60至70岁年龄组更常见。
在我们中心，结节病是老年患者非特发性葡萄膜炎的主要原因。特发性葡萄膜炎和其他疾病占病例不到三分之二。60岁以后眼科疾病很少见。我们还首次报告了70岁以后葡萄膜炎的特征。
