Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan School of Medicine, Seoul, Republic of Korea; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan School of Medicine, Seoul, Republic of Korea.
Bone. 2019 Oct;127:474-481. doi: 10.1016/j.bone.2019.07.018. Epub 2019 Jul 16.
The timed up-and-go (TUG) test is a validated screening tool to assess fall risk. This study evaluated the association between the TUG test and future fractures, which are a tangible clinical complication of falling.
We included 1,070,320 participants who participated in the National Screening Program for Transitional Ages for Koreans aged 66 years old from 2009 to 2014. Among them, 355,753 women underwent dual-energy X-ray absorptiometry. TUG times were classified as <10 s or ≥10 s. The incidence of fractures, including vertebral, hip, and other sites, was determined using claims data from the National Health Information database.
During the mean follow-up period of 4.4 ± 1.8 years, participants with slow TUG times had a significantly increased risk of fractures compared with those who had normal TUG times: any fractures (adjusted hazard ratio [aHR] = 1.08, 95% confidence interval [CI] = 1.06-1.10), vertebral fracture (aHR = 1.14, 95% CI = 1.11-1.16), hip fracture (aHR = 1.21, 95% CI = 1.13-1.29), and other fractures (upper arm, forearm, and lower leg; aHR = 1.02, 95% CI = 1.00-1.05). Among women with bone mineral density (BMD) results, slow TUG performance was associated with an increased risk of fracture independent of BMD.
The TUG test, as an indicator of physical performance, can provide information about future fracture risk above that provided by BMD. Conducting the TUG test to assess fracture risk should be considered to improve fracture risk assessment and propose interventions to improve physical performance, thereby reducing fracture risk.
计时起立行走测试（TUG）是一种经过验证的筛查工具，用于评估跌倒风险。本研究评估了 TUG 测试与未来骨折之间的关系，后者是跌倒的一种明显临床并发症。
我们纳入了 2009 年至 2014 年期间参加韩国全国 66 岁以上过渡期筛查计划的 1070320 名参与者。其中，355753 名女性接受了双能 X 线吸收法骨密度检查。TUG 时间分为<10s 或≥10s。通过国家健康信息数据库的索赔数据确定骨折的发生率，包括椎体、髋部和其他部位的骨折。
在平均 4.4±1.8 年的随访期间，与 TUG 时间正常的参与者相比，TUG 时间较慢的参与者发生骨折的风险显著增加：任何部位骨折（校正后的危险比[aHR] 1.08，95%置信区间[CI] 1.06-1.10）、椎体骨折（aHR 1.14，95%CI 1.11-1.16）、髋部骨折（aHR 1.21，95%CI 1.13-1.29）和其他部位骨折（上臂、前臂和小腿；aHR 1.02，95%CI 1.00-1.05）。在有骨密度（BMD）结果的女性中，TUG 表现缓慢与 BMD 无关，与骨折风险增加相关。
TUG 测试作为身体表现的指标，可以提供比 BMD 更多的关于未来骨折风险的信息。进行 TUG 测试以评估骨折风险应被考虑在内，以改善骨折风险评估并提出改善身体表现的干预措施，从而降低骨折风险。
