Department of Materials Science and Metallurgical Engineering, Electronic Microscopy Laboratory, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain.
Department of Materials Science and Metallurgical Engineering, Biomaterials, Biomechanics and Tissue Engineering Group, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain.
Colloids Surf B Biointerfaces. 2019 Oct 1;182:110317. doi: 10.1016/j.colsurfb.2019.06.047. Epub 2019 Jul 4.
Biomaterial-associated infections (BAI) are the major cause of failure of indwelling medical devices. The risk of BAI can end dramatically in the surgical removal of the affected device. Therefore, a major effort must be undertaken to guarantee the permanence of the implant. In this regard, we have developed antimicrobial coatings for tantalum (Ta) implants, using polyhydroxyalkanoates (PHAs) as matrices for carrying an active principle. The dip-coating technique was successfully used for covering solid Ta discs. An original PHA emulsion flow process was developed for the coating of porous Ta structures, specially for the inner surfaces. The complete characterization of the biopolymer coatings, their antibacterial properties, toxicity and biointegration were analyzed. Thus, non-toxic, well-biointegrated homogeneous biopolymer coatings were attained, which showed antibacterial properties. By using biodegradable PHAs, the resulting drug delivery system assured the protection of Ta against bacterial infections for a period of time.
生物材料相关性感染（BAI）是留置医疗设备失效的主要原因。通过手术移除受影响的设备，可以显著降低 BAI 的风险。因此，必须做出重大努力来保证植入物的持久性。在这方面，我们使用聚羟基烷酸酯（PHA）作为载体，开发了用于钽（Ta）植入物的抗菌涂层。采用浸涂技术成功地覆盖了固体 Ta 圆盘。开发了一种原始的 PHA 乳液流工艺，用于多孔 Ta 结构的涂层，特别是用于内表面。对生物聚合物涂层进行了完整的特性分析、抗菌性能、毒性和生物整合性分析。因此，获得了无毒、良好生物整合的均匀生物聚合物涂层，且具有抗菌性能。通过使用可生物降解的 PHAs，所得的药物输送系统确保 Ta 在一段时间内免受细菌感染。
