Yun C Chris
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Whitehead Research Bldg. Room 201, 615 Michael Street, Atlanta, GA 30322, USA.
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
Cancers (Basel). 2019 Jul 9;11(7):958. doi: 10.3390/cancers11070958.
The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the gut has been progressively appreciated. LPA signaling modulates cell proliferation, invasion, adhesion, angiogenesis, and survival that can promote cancer growth and metastasis. These effects are equally important for the maintenance of the epithelial barrier in the gut, which forms the first line of defense against the milieu of potentially pathogenic stimuli. This review focuses on the LPA-mediated signaling that potentially contributes to inflammation and tumor formation in the gastrointestinal tract.
肠上皮与免疫系统动态相互作用，以维持其屏障功能来保护宿主，同时在营养物质、电解质、水和矿物质的吸收中发挥生理作用。溶血磷脂酸（LPA）及其受体在肠道中的重要性已逐渐得到认可。LPA信号传导调节细胞增殖、侵袭、黏附、血管生成和存活，这些均可促进癌症生长和转移。这些作用对于维持肠道上皮屏障同样重要，肠道上皮屏障构成了抵御潜在致病刺激环境的第一道防线。本综述聚焦于LPA介导的信号传导，其可能在胃肠道炎症和肿瘤形成中发挥作用。
