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专为患有严重精神疾病的个体提供的药师管理的心血管疾病风险降低诊所。

A pharmacist-managed cardiovascular risk-reduction clinic for individuals experiencing serious mental illness.

出版信息

J Am Pharm Assoc (2003). 2019 Sep-Oct;59(5):698-703. doi: 10.1016/j.japh.2019.06.012. Epub 2019 Jul 16.

Abstract

OBJECTIVES

This retrospective analysis sought to: (1) characterize a cardiovascular risk-reduction clinic (CVRRC) patient population with serious mental illness (SMI); (2) analyze clinical outcomes of CVRRC patients over a 2-year period; and (3) compare outcomes for individuals prescribed different antipsychotic treatments in the CVRRC patient population over a 2-year period.

EVALUATION METHODS

In 2016, A pharmacist-managed CVRRC was implemented within a primary care clinic for patients with SMI. The CVRRC operates under a collaborative practice agreement allowing the pharmacist to initiate and change medications and order laboratory tests. Baseline data collected included demographic information, referring provider, tobacco use, and 10-year atherosclerotic cardiovascular disease risk. Data collected at subsequent visits included date of visit, A1C, estimated average glucose (eAG), blood pressure, weight, body mass index, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, statin and dose, tobacco use, amount smoked, and current antipsychotic treatment. Number of times that treatment for diabetes was initiated or intensified by the pharmacist or primary care provider was also collected.

IMPACT OF INNOVATION

A total of 101 patients were referred to the CVRRC over the 2-year period. Of these, 81 (80.2%) had at least 1 subsequent visit and were included in the A1C analysis. CVRRC patients had a statistically significant improvement in A1C over time. Mean A1C decreased by an increment of 0.06% for each month increase in follow-up time (P < 0.0001). There was no significant difference in A1C values between patients on different antipsychotic treatments (P = 0.74).

CONCLUSION

The pharmacist-managed CVRRC demonstrated beneficial outcomes for individuals diagnosed with diabetes and SMI. Results provide promising evidence supporting future larger studies to confirm these findings. Considering the morbidity and mortality disparities for individuals with SMI, health care organizations should consider similar models to improve diabetes outcomes.

摘要

目的

本回顾性分析旨在:(1)描述一个有严重精神疾病(SMI)的心血管风险降低诊所(CVRRC)患者人群;(2)分析 CVRRC 患者在两年内的临床结果;(3)比较 CVRRC 患者在两年内使用不同抗精神病药物治疗的结果。

评估方法

2016 年,在一家为 SMI 患者提供服务的初级保健诊所内实施了由药剂师管理的 CVRRC。CVRRC 是在合作实践协议下运作的,允许药剂师启动和改变药物治疗并开实验室检查。收集的基线数据包括人口统计学信息、转诊医生、吸烟情况以及 10 年动脉粥样硬化性心血管疾病风险。在随后的就诊中收集的数据包括就诊日期、A1C、估计平均血糖(eAG)、血压、体重、体重指数、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇、他汀类药物及其剂量、吸烟情况、吸烟量以及当前的抗精神病药物治疗。还收集了药剂师或初级保健提供者开始或加强治疗糖尿病的次数。

创新的影响

在两年内,共有 101 名患者被转诊到 CVRRC。其中,81 名(80.2%)至少有一次后续就诊,并且纳入了 A1C 分析。CVRRC 患者的 A1C 随着时间的推移有显著改善。A1C 随着随访时间的增加,每月增加 0.06%(P<0.0001)。使用不同抗精神病药物治疗的患者之间的 A1C 值没有显著差异(P=0.74)。

结论

由药剂师管理的 CVRRC 为诊断为糖尿病和 SMI 的个体带来了有益的结果。结果为支持未来更大规模研究以确认这些发现提供了有希望的证据。考虑到 SMI 患者的发病率和死亡率差距,医疗保健组织应考虑类似的模式来改善糖尿病的结果。

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