Department of Conservative Dentistry, Medical University of Warsaw, Warsaw, Poland.
Department of Periodontology, Medical University of Warsaw, Warsaw, Poland.
Arch Immunol Ther Exp (Warsz). 2019 Dec;67(6):367-373. doi: 10.1007/s00005-019-00555-4. Epub 2019 Jul 19.
This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe periodontitis. The significance of this test for prevention of periodontitis and its therapy has been discussed. IL-1 polymorphisms have been presented and described according to the reference single nucleotide polymorphism (SNP) identification number (rsID), established to eradicate the redundancy of reported polymorphisms in the SNP database processed by the National Center for Biotechnology Information. The prevalence of these genotypes in different populations and ethnic groups and its effect on periodontal health have been discussed. The presented data show inconsistent results. It seems that at least two polymorphisms, rs1800587 and rs1143634, are associated with periodontal inflammation. Therefore, they can be regarded as candidate genes involved in further periodontitis risk assessment. It seems that geographical and ethnical factors can play a great role, as the prevalence of specific polymorphisms varies greatly depending on the population studied.
本文介绍了白细胞介素 1A 和白细胞介素 1B 基因多态性在牙周炎中的作用的现有知识。本文关注了 IL-1 在疾病发病机制中的作用，以及基因检测的意义，即调查 IL-1 基因复合两种多态性的存在是否是重度牙周炎的危险因素。本文还讨论了该检测在预防和治疗牙周炎方面的意义。根据参考单核苷酸多态性 (SNP) 鉴定号 (rsID) 介绍和描述了白细胞介素 1 多态性，该编号的建立是为了消除由国家生物技术信息中心处理的 SNP 数据库中报告的多态性冗余。本文还讨论了这些基因型在不同人群和种族中的流行情况及其对牙周健康的影响。目前的研究结果存在不一致的情况。至少有两种多态性，即 rs1800587 和 rs1143634，与牙周炎炎症有关。因此，它们可以被视为参与进一步评估牙周炎风险的候选基因。地理位置和种族因素可能起着重要作用，因为特定多态性的流行程度因所研究的人群而异。
