Huang Wei, He Bing-Yang, Shao Jun, Jia Xiao-Wei, Yuan Ya-Di
Department of Stomatology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated With Jinan University, Zhuhai 519099, Guangdong Province, China.
Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Oncotarget. 2017 May 9;8(19):31406-31414. doi: 10.18632/oncotarget.15612.
Association between interleukin-1 beta (IL-1β) rs1143627 polymorphism and periodontal disease susceptibility was inconsistent; hence we performed this meta-analysis to explore the precise correlation between them. The degree of association was appraised through calculating pooled odds ratio (OR) and its 95% confidence interval (CI). The databases known as PubMed, Embase, and Chinese National Knowledge Infrastructure were searched up to October 26, 2016. A total of 8 eligible case-control studies were finally included, which involved 229 aggressive periodontitis patients, 382 chronic periodontitis patients, and 555 healthy controls. All the five genetic models revealed a non-significant association between IL-1β rs1143627 polymorphism and periodontal disease susceptibility (TT vs. CC: OR = 1.22, 95% CI = 0.80-1.87; CT+TT vs. CC: OR = 0.66, 95% CI = 0.44-1.01; TT vs. CT + CC: OR = 1.19, 95% CI = 0.81-1.74; T vs. C: OR = 0.92, 95% CI = 0.81-1.12; CT vs. CC: OR = 0.92, 95% CI = 0.69-1.23). Sensitivity analyses indicated that the results were robust and the subgroup analyses reached similar conclusions. IL-1β rs1143627 polymorphism is not related to periodontal disease susceptibility in the overall population based on the current evidence, but further studies are required in more large scale sample size with risk factor adjusted.
白细胞介素-1β（IL-1β）rs1143627多态性与牙周病易感性之间的关联并不一致；因此，我们进行了这项荟萃分析，以探讨它们之间的确切相关性。通过计算合并比值比（OR）及其95%置信区间（CI）来评估关联程度。检索了截至2016年10月26日的PubMed、Embase和中国知网数据库。最终纳入了8项符合条件的病例对照研究，其中包括229例侵袭性牙周炎患者、382例慢性牙周炎患者和555例健康对照。所有五种遗传模型均显示IL-1β rs1143627多态性与牙周病易感性之间无显著关联（TT与CC：OR = 1.22，95%CI = 0.80 - 1.87；CT + TT与CC：OR = 0.66，95%CI = 0.44 - 1.01；TT与CT + CC：OR = 1.19，95%CI = 0.81 - 1.74；T与C：OR = 0.92，95%CI = 0.81 - 1.12；CT与CC：OR = 0.92，95%CI = 0.69 - 1.23）。敏感性分析表明结果稳健，亚组分析得出了相似的结论。基于目前的证据，IL-1β rs1143627多态性与总体人群的牙周病易感性无关，但需要在更大样本量且调整了危险因素的情况下进行进一步研究。
