Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil; Post Graduation Program in Biomedical Sciences, Federal University of Piaui, Parnaiba, Piaui, Brazil.
Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, PI, Brazil.
Gene. 2018 Aug 20;668:97-106. doi: 10.1016/j.gene.2018.05.067. Epub 2018 May 18.
Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5.2 statistical software with Odds Ratio (OR) calculation and Funnel plot (P < 0.05) to heterogeneity and the Comprehensive Meta-analysis version 3.3.070 to assessment publication bias by Egger's and Begg's tests. In overall, 54 case/control studies composed the meta-analysis. T allele was significantly associated with patients case (OR = 1.35, 95% CI: 1.24, 1.48, P < 0.00001) in the overall analysis. The stratified evaluation showed the rs1143634 polymorphism had significant association with disease in Caucasian, Asian and mixed population was excepted in African ethnicity (P > 0.05). No publication bias was found in allelic evaluation. This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population.
有几个因素与宿主反应中的牙周炎有关，包括细胞因子以及细胞因子基因多态性的影响，但结果仍存在争议。本研究旨在评估白细胞介素-1B 基因（细胞因子基因）中的 rs1143634 多态性与慢性牙周炎的风险，并进行了一项重点关注种族的荟萃分析。在几个数据库中进行了文献综述，以检索到 2017 年 6 月之前发表的研究。由两位校准的调查员进行数据提取，通过 Review Manager 版本 5.2 统计软件计算荟萃分析，计算比值比（OR）和漏斗图（P<0.05）以评估异质性，使用 Comprehensive Meta-analysis 版本 3.3.070 通过 Egger 和 Begg 检验评估发表偏倚。总体而言，54 项病例对照研究构成了荟萃分析。在整体分析中，T 等位基因与患者病例显著相关（OR=1.35，95%CI：1.24，1.48，P<0.00001）。分层评估显示，rs1143634 多态性与白种人、亚洲人和混合人群的疾病有显著关联，但在非洲人群中无显著关联（P>0.05）。等位基因评估未发现发表偏倚。这项纳入 9376 名参与者的 54 项病例对照研究的荟萃分析表明，rs1143634 多态性与慢性牙周炎的总体风险以及白种人、亚洲人和混合人群的风险增加相关。
