Fundación Biociencia, José Domingo Cañas 2280, Ñuñoa, Santiago, Chile.
Departamento de Ingeniería Química, Universidad de Santiago de Chile, Alameda 3363, Estación Central, Santiago, Chile.
Extremophiles. 2020 Jan;24(1):43-52. doi: 10.1007/s00792-019-01111-w. Epub 2019 Jul 19.
Violacein is an intensely purple pigment synthesized by various genera of bacteria that has been discovered to have a wide range of interesting biological activities which range from anticarcinogenic to antibacterial. One of the hindrances for its real-life application is that the first microorganisms found to produce the compound may act as opportunistic pathogens. Here, we report the isolation and characterization of violacein from a non-pathogenic Antarctic Iodobacter strain. Its anti-microbial properties were also tested. The method proposed here for the purification of violacein shows high yields, indicating that this Antarctic microorganism could be a valuable source for this important pigment. This is the first characterization of violacein from an Antarctic Iodobacter strain and here we also present a viable method to obtain this pigment for potential biotechnological applications.
紫灰菌素是一种由多种细菌属合成的深紫色色素,现已发现其具有广泛的有趣的生物活性,从抗癌到抗菌。其实际应用的一个障碍是,最初发现产生该化合物的微生物可能是机会性病原体。在这里,我们报告了一种非致病性南极碘杆菌中紫灰菌素的分离和特性。还测试了其抗菌特性。这里提出的紫灰菌素的纯化方法显示出高产量,表明这种南极微生物可能是这种重要色素的有价值的来源。这是首次对南极碘杆菌菌株中的紫灰菌素进行表征,我们还提出了一种可行的方法来获得这种色素,以用于潜在的生物技术应用。