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男性不育夫妇中性功能障碍的症状:患病率及与睾酮缺乏的关系。

Symptoms of sexual dysfunction among men from infertile couples: prevalence and association with testosterone deficiency.

机构信息

Reproductive Medicine Center, Skåne University Hospital, Malmoe, Sweden.

Faculty of Health and Society, Department of Care Science, Malmoe University, Malmoe, Sweden.

出版信息

Andrology. 2020 Jan;8(1):160-165. doi: 10.1111/andr.12678. Epub 2019 Jul 19.

Abstract

BACKGROUND

This case control study aimed to investigate whether symptoms of sexual dysfunction are more common in males from infertile couples than in the general population and to explore whether symptoms of sexual dysfunction are associated to hypogonadism.

OBJECTIVES

Participants were 165 subfertile men in infertile heterosexual relationships, 18-50 years of age, with sperm concentrations < 15 × 10 /mL. The controls were 199 men from a population-based group, matched for age.

MATERIAL AND METHODS

Logistic regression was applied in order to calculate odds ratios (ORs) for seven different symptoms of sexual dysfunction. In a multivariate model, we tested independent effects of infertility and primary as well as secondary hypogonadism.

RESULTS

Statistically significant association between subfertility and symptoms of sexual dysfunction was found for lack of ability to control ejaculation (OR 2.2, 95% CI: 1.2-4.2). For hypogonadism, statistical significance was seen both in relation to low sexual interest/desire for sex (OR 2.3, 95% CI: 1.0-5.5) and for being worried about the size or shape of the penis (OR 3.6, 95% CI: 1.3-9.5). These associations remained statistically significant in males with primary but not those with secondary hypogonadism.

DISCUSSION

Our study showed that men from infertile couples have an increased risk of symptoms of sexual dysfunction and this risk is linked to androgen deficiency.

CONCLUSION

Assessment of reproductive hormone levels and sexual function should routinely be done in this group of males.

摘要

背景

本病例对照研究旨在探讨不孕夫妇男性的性功能障碍症状是否比一般人群更常见,并探讨性功能障碍症状是否与性腺功能减退有关。

目的

参与者为 165 名年龄在 18-50 岁、精子浓度<15×10/ml 的不孕异性恋关系中存在生育力问题的男性。对照组为 199 名年龄匹配的基于人群的男性。

材料和方法

应用逻辑回归计算七种不同性功能障碍症状的比值比(OR)。在多变量模型中,我们测试了不孕和原发性及继发性性腺功能减退的独立影响。

结果

不孕与缺乏控制射精能力(OR 2.2,95%CI:1.2-4.2)之间存在统计学显著关联。对于性腺功能减退,在低性欲/对性的欲望(OR 2.3,95%CI:1.0-5.5)和担心阴茎的大小或形状(OR 3.6,95%CI:1.3-9.5)方面均存在统计学意义。这些关联在原发性性腺功能减退的男性中具有统计学意义,但在继发性性腺功能减退的男性中则没有。

讨论

我们的研究表明,不孕夫妇的男性性功能障碍症状风险增加,这种风险与雄激素缺乏有关。

结论

应常规对这组男性进行生殖激素水平和性功能评估。

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