Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.
Neurobiol Learn Mem. 2019 Oct;164:107047. doi: 10.1016/j.nlm.2019.107047. Epub 2019 Jul 17.
Reactivation renders consolidated memory labile again, and the ensuing temporary reconsolidation process is highly susceptible to mnemonic modification. Here, we show that memories in such an unstable state could be influenced by sheer behavioral means, bypassing the need for pharmacological intervention. Across several experiments using a "face-location association" paradigm in which participants experienced a "Learning - New-learning - Final-test" procedure, we demonstrate that reactivated memory traces were hampered when the new learning was strategically administered at between 0-min and 20-min delay. Using fMRI, we further advance our theoretical understanding that this lability can be mechanistically explained by the differential activation in the hippocampal-amygdala memory system implicated by the post-activation new-learning whereas the mnemonic intrusion caused by newly learned memories is efficaciously reconciled by the left inferior frontal gyrus.
重新激活使已巩固的记忆再次变得不稳定，随后的暂时再巩固过程极易受到记忆修饰的影响。在这里，我们表明，在这种不稳定状态下的记忆可以通过纯粹的行为手段来影响，而无需药物干预。在几个使用“面部-位置关联”范式的实验中，参与者经历了“学习-新学习-最终测试”的过程，我们证明，当新学习在 0 分钟至 20 分钟的延迟时间内被策略性地给予时，被重新激活的记忆痕迹会受到阻碍。使用 fMRI，我们进一步深入了解到，这种不稳定性可以通过海马-杏仁核记忆系统的差异激活来在机制上得到解释，这是由新学习后的激活引起的，而新学习的记忆引起的记忆入侵则被左额下回有效地调和。
