Saarland Cancer Registry, D-66119 Saarbrücken, Germany.
Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany.
Cancer Epidemiol. 2019 Oct;62:101562. doi: 10.1016/j.canep.2019.07.001. Epub 2019 Jul 17.
Meningiomas are mostly benign tumors that originate from the coverings of the brain and spinal cord. Compared to malignant glial tumors, meningiomas are relatively understudied with regard to their risk factors and epidemiology. In particular, population-based data on cancer burden and patient outcomes are scant.
Population-based data from Saarland, a federal state in South-Western Germany, were used; the data included 992 patients diagnosed with a first meningioma between 2000 and 2015. Incidence and mortality rates-as well as estimates of observed and relative survival and cumulative incidence of tumor recurrence up to 10 years after diagnosis-were derived by sex, age, WHO grade, and whether or not the patient had undergone surgery.
This population-based study not only included patients treated in the regional university hospital but also those treated elsewhere or patients without any surgical treatment. The mean age of the patients at diagnosis was 63 years, and 70%, 28% and 3% had WHO grade I, II and III meningiomas, respectively. Ten-year observed and relative survival of all patients combined was 72% and 91% respectively. Tumor-related mortality varied by sex and increased with age at diagnosis and the WHO grade of the tumor. The overall 10-year cumulative incidence of meningioma recurrence was 9%.
This analysis represents the first modern population-based analysis of meningioma incidence and mortality and outcomes of patients with such neoplasms in Germany. Derived from an unselected sample of patients, this study may fill a hitherto existing gap in the literature on meningiomas.
脑膜瘤大多为良性肿瘤，起源于脑和脊髓的覆盖物。与恶性神经胶质瘤相比，脑膜瘤的风险因素和流行病学研究相对较少。特别是，关于癌症负担和患者预后的基于人群的数据很少。
利用德国西南部萨尔州的基于人群的数据；这些数据包括 992 名在 2000 年至 2015 年间被诊断为首次脑膜瘤的患者。通过性别、年龄、世界卫生组织（WHO）分级以及患者是否接受手术，得出发病率和死亡率，以及观察生存率、相对生存率和肿瘤复发累积发生率的估计值，随访时间长达 10 年。
本基于人群的研究不仅包括在地区大学医院接受治疗的患者，还包括在其他地方接受治疗或未接受任何手术治疗的患者。患者诊断时的平均年龄为 63 岁，70%、28%和 3%的患者分别患有 WHO 分级 I、II 和 III 级脑膜瘤。所有患者的 10 年观察生存率和相对生存率分别为 72%和 91%。肿瘤相关死亡率因性别而异，并随诊断时的年龄和肿瘤的 WHO 分级而增加。脑膜瘤复发的总 10 年累积发生率为 9%。
该分析代表了德国首次对脑膜瘤发病率、死亡率以及此类肿瘤患者预后的现代基于人群的分析。该研究来源于未选择的患者样本，可能填补了脑膜瘤文献中的一个空白。
