白细胞介素-32 在冠状动脉和冠心病患者的血浆中增加。

Interleukin-32 increases in coronary arteries and plasma from patients with coronary artery disease.

机构信息

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.

出版信息

Clin Chim Acta. 2019 Oct;497:104-109. doi: 10.1016/j.cca.2019.07.019. Epub 2019 Jul 19.

DOI:10.1016/j.cca.2019.07.019

PMID:31326419

Abstract

BACKGROUND

Interleukin-32 (IL-32) is a cytokine associated with higher risk of cardiovascular diseases in inflammatory environments. This study aimed to investigate the IL-32 levels in coronary artery disease (CAD) patients.

METHODS

IL-32 expression in coronary arteries from both normal donors and CAD patients were analyzed. Plasma IL-32, IFN-γ and IL-17 levels in stable angina pectoris (SAP, n = 80) patients, unstable angina pectoris (UAP, n = 96) patients, acute myocardial infarction (AMI, n = 72) patients and patients exhibiting chest pain unrelated to coronary artery disease (NCAD, n = 72) were measured. Additionally, whether plasma IL-32 levels were independent correlated with the presence of CAD was analyzed.

RESULTS

IL-32 was high expressed in atherosclerotic plaques of CAD patients when compared with normal coronary arteries, and macrophages were the major sources of IL-32. Compared with the NCAD group, IL-32, IFN-γ and IL-17 levels were increased in the CAD group and gradually increased through the SAP, UAP and AMI groups. Plasma IL-32 levels were positively correlated with the Gensini score, IFN-γ levels and IL-17 levels in CAD patients. The results of linear regression showed that IL-32 was independently associated with the occurrence of CAD.

CONCLUSION

Both the coronary artery and circulating IL-32 levels were increased in CAD patients and IL-32 may be a marker of noninvasive diagnosis of CAD.

摘要

背景

白细胞介素-32（IL-32）是一种细胞因子，与炎症环境中心血管疾病的高风险相关。本研究旨在探讨冠心病（CAD）患者的 IL-32 水平。

方法

分析正常供体和 CAD 患者冠状动脉中的 IL-32 表达。测量稳定型心绞痛（SAP，n=80）患者、不稳定型心绞痛（UAP，n=96）患者、急性心肌梗死（AMI，n=72）患者和胸痛与冠状动脉疾病无关的患者（NCAD，n=72）的血浆 IL-32、IFN-γ 和 IL-17 水平。此外，还分析了血浆 IL-32 水平是否与 CAD 的存在独立相关。

结果

与正常冠状动脉相比，CAD 患者的动脉粥样硬化斑块中 IL-32 表达较高，且巨噬细胞是 IL-32 的主要来源。与 NCAD 组相比，IL-32、IFN-γ 和 IL-17 水平在 CAD 组中升高，并在 SAP、UAP 和 AMI 组中逐渐升高。血浆 IL-32 水平与 CAD 患者的 Gensini 评分、IFN-γ 水平和 IL-17 水平呈正相关。线性回归结果表明，IL-32 与 CAD 的发生独立相关。