Ogawa Daisuke, Kobayashi Shinji, Yamazaki Kenji, Motomura Tadashi, Nishimura Takashi, Shimamura Junichi, Tsukiya Tomonori, Mizuno Toshihide, Takewa Yoshiaki, Tatsumi Eisuke
Sun Medical Technology Research Corp., 2990 Shiga, Suwa-city, Nagano, 392-0012, Japan.
Hokkaido Cardiovascular Hospital, 13 Chome-1-30 Minami 27 Jonishi, Chuo Ward, Sapporo, Hokkaido, Japan.
J Artif Organs. 2019 Dec;22(4):276-285. doi: 10.1007/s10047-019-01117-3. Epub 2019 Jul 20.
We studied a control method of rotary blood pumps (RBPs), which is called as the cardiac beat synchronization (CBS) system. Usually, RBPs operate at constant target rotational speed, meanwhile, the CBS system modulates target speed synchronizing with cardiac beat. We built a computer simulation method to evaluate the CBS system. This simulator acquires a mathematical model of a circulatory system including a RBP and can provide us the theoretical hemodynamics when our control method is applied. We compared theoretical results with experimental ones with the model focusing on both pulsatility and aortic valve (AV) opening interval enhanced by the CBS system. Our simulator could reproduce behavior of the circulatory system whether the RBP is connected or not. Comparison among no RBP, constant assist, systolic assist, and diastolic assist modes indicated that pulsatility is enhanced with systolic assist theoretically. While systolic assist decreased AV opening interval, diastolic assist made it longer than the ones in other control strategies.
我们研究了一种旋转血泵（RBP）的控制方法，即心跳同步（CBS）系统。通常，RBP以恒定的目标转速运行，而CBS系统则与心跳同步调制目标转速。我们建立了一种计算机模拟方法来评估CBS系统。该模拟器获取了包括RBP在内的循环系统的数学模型，并能在应用我们的控制方法时为我们提供理论血流动力学数据。我们将理论结果与模型实验结果进行了比较，重点关注CBS系统增强的搏动性和主动脉瓣（AV）开放间隔。无论RBP是否连接，我们的模拟器都能重现循环系统的行为。无RBP、恒定辅助、收缩期辅助和舒张期辅助模式之间的比较表明，理论上收缩期辅助可增强搏动性。虽然收缩期辅助缩短了AV开放间隔，但舒张期辅助使其比其他控制策略中的开放间隔更长。
