Department of Pharmacy, UW Health, Madison, WI, USA.
School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Diagn Microbiol Infect Dis. 2019 Nov;95(3):114857. doi: 10.1016/j.diagmicrobio.2019.06.009. Epub 2019 Jun 22.
In response to the antimicrobial resistance crisis, pharmaceutical industry reinvested in and produced new antibiotics. Antimicrobial stewardship programs influence optimal antimicrobial use, which often places them at the cross-roads of resistance and treatments. We surveyed a clinical administration database of US medical centers between 2014 and 2018 for index antimicrobial utilization date of six Qualified Infectious Diseases Products (QIDP). Among 132 hospitals identified, the median time to use any agent was 398 days (range 13 to >1478 days). QIDP antibiotic use was more likely among academic medical centers (range 34%-88%) and hospitals >400 beds (range 39%-86%) compared to non-academic medical center (3-51%) and smaller and hospitals (range 0-61%). The South was quickest to use all QIDP (median 733 days), while the Northeast was longest at 1370 days. New antimicrobials have limited clinical use, which impacts manufacturers' ability to stay in the antimicrobial market and further risking a depleted antimicrobial pipeline.
针对抗菌药物耐药性危机，制药行业重新投资并生产了新的抗生素。抗菌药物管理计划影响最佳抗菌药物的使用，这往往使它们处于耐药性和治疗的交叉点。我们调查了 2014 年至 2018 年期间美国医疗中心的临床管理数据库，以确定六种合格的传染病产品（QIDP）的指数抗菌药物使用日期。在确定的 132 家医院中，任何药物的中位使用时间为 398 天（范围为 13 至> 1478 天）。与非学术医疗中心（3-51%）和较小的医院（范围为 0-61%）相比，学术医疗中心（范围为 34%-88%）和>400 张病床的医院（范围为 39%-86%）更有可能使用 QIDP 抗生素。南方最快使用所有 QIDP（中位 733 天），而东北则最长为 1370 天。新的抗菌药物的临床应用有限，这影响了制造商在抗菌药物市场中的生存能力，并进一步增加了抗菌药物管道枯竭的风险。
