Pannekoek Willem-Jan, de Rooij Johan, Gloerich Martijn
Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
F1000Res. 2019 Jul 10;8. doi: 10.12688/f1000research.18779.1. eCollection 2019.
Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Moreover, components of cadherin adhesions adopt force-dependent conformations that induce changes in the composition of adherens junctions, enabling transduction of mechanical forces into an intracellular response. Cadherin mechanotransduction can mediate reinforcement of cell-cell adhesions to withstand forces but also induce biochemical signaling to regulate cell behavior or direct remodeling of cell-cell adhesions to enable cell rearrangements. By transmission and transduction of mechanical forces, cadherin adhesions coordinate cellular behaviors underlying morphogenetic processes of collective cell migration, cell division, and cell intercalation. Here, we review recent advances in our understanding of this central role of cadherin adhesions in force-dependent regulation of morphogenesis.
机械力在形态发生过程中驱动组织重塑。这依赖于基于钙黏蛋白的黏附连接在细胞间传递力，该连接将相邻细胞产生力的肌动球蛋白细胞骨架连接起来。此外，钙黏蛋白黏附的成分会采用力依赖的构象，从而诱导黏附连接组成的变化，使机械力能够转导为细胞内反应。钙黏蛋白的力转导可以介导细胞间黏附的增强以承受力，还能诱导生化信号传导来调节细胞行为，或直接重塑细胞间黏附以实现细胞重排。通过机械力的传递和转导，钙黏蛋白黏附协调了集体细胞迁移、细胞分裂和细胞插入等形态发生过程中潜在的细胞行为。在此，我们综述了近期在理解钙黏蛋白黏附在力依赖的形态发生调节中的核心作用方面取得的进展。
