Department of Cytology and Gynecologic Pathology, PGIMER, Chandigarh, India.
Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
J Adolesc Young Adult Oncol. 2019 Dec;8(6):702-706. doi: 10.1089/jayao.2019.0048. Epub 2019 Jul 22.
Primary ovarian non-Hodgkin lymphoma (PONHL) is extremely rare, accounting for 0.5% of all NHLs and 1.5% of all ovarian tumors. Establishing an early and accurate clinical as well as histopathological diagnosis, although challenging, is essential for the appropriate management of these patients and to avoid unnecessary surgeries. Furthermore, it is important to exclude secondary involvement of the ovary by disseminated NHL in these patients, as the two entities carry significantly different prognosis. The diagnostic struggle is mainly due to its rarity, morphological similarities with other malignancies and the relative lack of awareness among the histopathologists. In this article, we present a case of primary ovarian diffuse large B cell lymphoma in a young nulliparous female, who was diagnosed based on histopathological and immunohistochemical findings.
原发性卵巢非霍奇金淋巴瘤（PONHL）极为罕见，占所有 NHL 的 0.5%，占所有卵巢肿瘤的 1.5%。尽管建立早期和准确的临床及组织病理学诊断具有挑战性，但对于这些患者的适当管理和避免不必要的手术至关重要。此外，重要的是要排除这些患者中弥漫性 NHL 对卵巢的继发性累及，因为这两种情况具有显著不同的预后。诊断的困难主要是由于其罕见性、与其他恶性肿瘤的形态相似性以及组织病理学家的相对缺乏认识。本文介绍了一名年轻未育女性的原发性卵巢弥漫性大 B 细胞淋巴瘤病例，该病例基于组织病理学和免疫组织化学发现进行诊断。
