Tross S, Price R W, Navia B, Thaler H T, Gold J, Hirsch D A, Sidtis J J
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York 10021.
AIDS. 1988 Apr;2(2):81-8. doi: 10.1097/00002030-198804000-00002.
The AIDS dementia complex (ADC) is a frequent complication of advanced HIV infection. In order to better define the neuropsychological character and progression of the ADC, four groups of subjects were studied with a battery of neuropsychological tests: an HIV-seronegative comparison group (n = 20), asymptomatic HIV-seropositive patients (n = 16), newly diagnosed AIDS patients (n = 44) and AIDS patients who were referred for neurological consultation (n = 40). Results showed significant reductions in performance in the two AIDS groups, with impairment being most prominent in tests that assessed motor speed and fine control, concentration, problem solving and visuospatial performance. This pattern of neuropsychological dysfunction is consistent with the characterization of the ADC as a subcortical dementia.
艾滋病痴呆综合征（ADC）是晚期HIV感染常见的并发症。为了更好地界定ADC的神经心理学特征和进展情况，使用一系列神经心理学测试对四组受试者进行了研究：HIV血清反应阴性的对照组（n = 20）、无症状HIV血清反应阳性患者（n = 16）、新诊断的艾滋病患者（n = 44）以及因神经问题前来咨询的艾滋病患者（n = 40）。结果显示，两个艾滋病组的测试表现显著下降，在评估运动速度和精细控制、注意力、解决问题能力以及视觉空间表现的测试中，损伤最为明显。这种神经心理学功能障碍模式与将ADC描述为皮质下痴呆相符。
