艾滋病患者及无症状HIV血清阳性患者的神经心理学异常
Neuropsychological abnormalities in AIDS and asymptomatic HIV seropositive patients.
作者信息
Villa G, Monteleone D, Marra C, Bartoli A, Antinori A, Pallavicini F, Tamburrini E, Izzi I
机构信息
Servizio di Neuropsicologia, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):878-84. doi: 10.1136/jnnp.56.8.878.
Neuropsychological and immunological parameters were studied in 36 AIDS patients with early disease and without clinical, laboratory, and neuroradiological signs of CNS impairment, and also in 33 asymptomatic HIV seropositive subjects. Many AIDS patients performed abnormally on timed psychomotor tasks, tasks involving sequencing and "set-shifting", and memory tasks stressing attention, learning, active retrieval, and monitoring of information. Asymptomatic HIV seropositive subjects as a group did not perform significantly worse than controls. However, on the basis of a cut off number of pathological performances on neuropsychological tasks, 52.8% of AIDS and 30.3% of asymptomatic HIV seropositive subjects had cognitive impairment, compared with 3.9% of HIV seronegative controls. Low values of CD4+ cells and of CD4+/CD8+ ratio and high titres of P-24 antigen in the blood prevailed among subjects with cognitive impairment, especially in the asymptomatic HIV seropositive group.
对36例处于疾病早期且无中枢神经系统损害的临床、实验室及神经放射学征象的艾滋病患者，以及33例无症状的HIV血清阳性者进行了神经心理学和免疫学参数研究。许多艾滋病患者在定时精神运动任务、涉及序列和“转换定势”的任务以及强调注意力、学习、主动检索和信息监测的记忆任务中表现异常。无症状的HIV血清阳性者作为一个群体，其表现并不比对照组明显更差。然而，根据神经心理学任务中病理性表现的临界值数量，52.8%的艾滋病患者和30.3%的无症状HIV血清阳性者存在认知障碍，而HIV血清阴性对照组这一比例为3.9%。认知障碍患者中，尤其是无症状HIV血清阳性组，血液中CD4 + 细胞和CD4+/CD8 + 比值较低，P - 24抗原滴度较高。
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