Pistone Alessandro, Celesti Consuelo, Piperopoulos Elpida, Ashok Deepu, Cembran Arianna, Tricoli Antonio, Nisbet David
Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy.
Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra ACT 2601, Australia.
Materials (Basel). 2019 Jul 20;12(14):2321. doi: 10.3390/ma12142321.
Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.
作为用于骨组织工程的骨传导生物材料开发的创新系统，生物可吸收材料受到了越来越多的关注。在本文中，通过原位沉淀技术在壳聚糖基质中添加羟基磷灰石和/或磁铁矿合成了壳聚糖基复合材料。通过光学和电子显微镜、热重分析（TGA）、X射线衍射（XRD）以及体外细胞培养研究对复合材料进行了表征。发现羟基磷灰石和磁铁矿均匀分散在壳聚糖基质中，并且复合材料表现出优异的生物相容性以及支持细胞附着和增殖的能力；特别是，壳聚糖/羟基磷灰石/磁铁矿复合材料（CS/HA/MGN）相对于纯壳聚糖（CS）和壳聚糖/羟基磷灰石（CS/HA）支架表现出优异的生物活性。
