The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Psychology Department, Anglia Ruskin University, Cambridge, UK.
Leuk Lymphoma. 2019 Dec;60(14):3449-3454. doi: 10.1080/10428194.2019.1641803. Epub 2019 Jul 22.
Hodgkin lymphoma (HL) is common in young adults and considered curable in most patients. Young HL survivors (HLS) are at risk of long-term adverse effects. Our study aimed to assess various fatigue and quality of life (QoL) complaints, and their correlations with treatment. Self-reported questionnaires assessing fatigue (MFI-20) and QoL-related issues (EORTC-QOL-C-30) were used to examine HLS aged 18-65 who completed first-line chemotherapy ± radiotherapy (RT) and were in complete remission for at least six months post-therapy. The cohort included 120 HLS (median age 32 years), assessed between 6 months and 15 years post-treatment. About 28% presented with severe fatigue and severely reduced QoL. Higher fatigue levels were associated with four cycles of the ABVD + RT. Young HLS experience high levels of persistent physical fatigue, emotional distress, and cognitive decline that are insufficiently investigated. Assessment of these complaints is essential and further investigation may provide tailored solutions for a better QoL for HLS.
霍奇金淋巴瘤（HL）在年轻人中较为常见，大多数患者可被治愈。年轻 HL 幸存者（HLS）存在长期不良影响的风险。我们的研究旨在评估各种疲劳和生活质量（QoL）问题，并探讨其与治疗的相关性。本研究使用自我报告问卷评估了 18-65 岁的 HLS，这些患者完成了一线化疗±放疗（RT），且在治疗后至少 6 个月完全缓解。队列纳入了 120 名 HLS（中位年龄 32 岁），在治疗后 6 个月至 15 年内进行了评估。约 28%的患者存在严重疲劳和严重降低的 QoL。更高的疲劳水平与 ABVD+RT 四个周期相关。年轻的 HL 幸存者经历了较高水平的持续性身体疲劳、情绪困扰和认知能力下降，但这些问题尚未得到充分研究。评估这些不适非常重要，进一步的研究可能为 HLS 提供更好的 QoL 提供针对性的解决方案。
