Mancuso Salvatrice, Mattana Marta, Giammancheri Federica, Russello Federica, Carlisi Melania, Santoro Marco, Siragusa Sergio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Division of Hematology, University of Palermo, Palermo, Italy.
Front Oncol. 2024 Feb 9;14:1201595. doi: 10.3389/fonc.2024.1201595. eCollection 2024.
In the recent decades, remarkable successes have been recorded in the treatment of Hodgkin's lymphoma to the point that today it represents one of the neoplasms with the highest rates of cure and with the highest life expectancy. Nonetheless, this raises the concern for the health of long- term survivors. Late side effects of treatments in synergy with other risk factors expose survivors to increased morbidity and impaired quality of life. In the complexity of the topics concerning these last aspects, an area of growing interest is that of bone damage that follows Hodgkin Lymphoma and its treatments. In this narrative review, we conducted our work through assessment of available evidence focusing on several aspects linking bone damage and quality of life with Hodgkin lymphoma and its treatments. At present, the problem of osteopenia and osteoporosis in Hodgkin lymphoma survivors is a theme for which awareness and knowledge need to be implemented.
在最近几十年里,霍奇金淋巴瘤的治疗取得了显著成功,如今它已成为治愈率最高、预期寿命最长的肿瘤之一。尽管如此,这引发了对长期幸存者健康的担忧。治疗的晚期副作用与其他风险因素相互作用,使幸存者面临更高的发病率和生活质量受损的问题。在涉及这些最后方面的复杂主题中,一个日益受到关注的领域是霍奇金淋巴瘤及其治疗后发生的骨损伤。在这篇叙述性综述中,我们通过评估现有证据开展工作,重点关注将骨损伤和生活质量与霍奇金淋巴瘤及其治疗联系起来的几个方面。目前,霍奇金淋巴瘤幸存者的骨质减少和骨质疏松问题是一个需要提高认识和知识的主题。