Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hotel-Dieu Hospital, AP-HP, Université Paris Descartes, 1 place du Parvis de Notre-Dame, Paris, France.
Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), 6-8 rue Saint-fiacre, 77100, Meaux, France.
J Exp Clin Cancer Res. 2019 Jul 22;38(1):323. doi: 10.1186/s13046-019-1320-y.
Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth and invasion by acting on both chronic inflammation and oxidative stress. This review focuses on the interest of use curcumin in cancer therapy by acting on the WNT/β-catenin pathway to repress chronic inflammation and oxidative stress. In the cancer process, one of the major signaling pathways involved is the WNT/β-catenin pathway, which appears to be upregulated. Curcumin administration participates to the downregulation of the WNT/β-catenin pathway and thus, through this action, in tumor growth control. Curcumin act as PPARγ agonists. The WNT/β-catenin pathway and PPARγ act in an opposed manner. Chronic inflammation, oxidative stress and circadian clock disruption are common and co-substantial pathological processes accompanying and promoting cancers. Circadian clock disruption related to the upregulation of the WNT/β-catenin pathway is involved in cancers. By stimulating PPARγ expression, curcumin can control circadian clocks through the regulation of many key circadian genes. The administration of curcumin in cancer treatment would thus appear to be an interesting therapeutic strategy, which acts through their role in regulating WNT/β-catenin pathway and PPARγ activity levels.
许多研究表明姜黄素在癌症预防和肿瘤治疗中可能有积极作用。有几种假说强调，姜黄素可以通过作用于慢性炎症和氧化应激来降低肿瘤生长和侵袭。本综述重点讨论了通过作用于 WNT/β-连环蛋白途径抑制慢性炎症和氧化应激来使用姜黄素进行癌症治疗的兴趣。在癌症过程中，涉及的主要信号通路之一是 WNT/β-连环蛋白途径，该途径似乎被上调。姜黄素的给药参与了 WNT/β-连环蛋白途径的下调，因此，通过这种作用，控制肿瘤生长。姜黄素作为 PPARγ 激动剂。WNT/β-连环蛋白途径和 PPARγ 以相反的方式起作用。慢性炎症、氧化应激和昼夜节律紊乱是伴随和促进癌症的常见且共同的病理性过程。与 WNT/β-连环蛋白途径上调相关的昼夜节律紊乱与癌症有关。通过刺激 PPARγ 表达，姜黄素可以通过调节许多关键的昼夜节律基因来控制生物钟。因此，在癌症治疗中使用姜黄素似乎是一种有趣的治疗策略，它通过调节 WNT/β-连环蛋白途径和 PPARγ 活性水平发挥作用。
