Langhorn Rebecca, Bochsen Louise, Willesen Jakob Lundgreen, Sørensen Tina Møller, Kristensen Annemarie Thuri
Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark.
Acta Vet Scand. 2019 Jul 22;61(1):35. doi: 10.1186/s13028-019-0469-x.
Thromboelastography (TEG) is a global whole blood hemostasis assay which includes plasma as well as cellular components of hemostasis in the analysis and follows the quality and dynamics of clot development, stabilization, and lysis. In human medicine TEG is also a valuable asset in the therapeutic setting, allowing evaluation of the effect of transfusion therapy in vitro. This case series describes the use of TEG as a guiding tool for transfusion therapy in four dogs with hypocoagulable hemostatic disorders.
Four dogs presented with hypocoagulable disorders of hemostasis, diagnosed as rodenticide intoxication, angiostrongylosis, disseminated intravascular coagulation following severe systemic inflammation, and immune-mediated thrombocytopenia, respectively. TEG was used as a diagnostic tool as well as a guiding tool in the decision of whether or not, and in what dose, fresh frozen plasma would be of benefit in the treatment protocol for each dog.
TEG may be applied in the therapeutic setting as a means to tailor individual patient transfusion therapy in critically ill dogs with hypocoagulable states.
血栓弹力图（TEG）是一种全面的全血止血检测方法，在分析过程中纳入了血浆以及止血的细胞成分，并跟踪血凝块形成、稳定和溶解的质量与动态变化。在人类医学中，TEG在治疗环境中也是一项宝贵的工具，可用于评估输血治疗在体外的效果。本病例系列描述了TEG作为四只患有低凝性止血障碍犬输血治疗指导工具的应用情况。
四只犬分别因杀鼠剂中毒、广州管圆线虫病、严重全身炎症后发生的弥散性血管内凝血以及免疫介导性血小板减少症而出现低凝性止血障碍。TEG被用作诊断工具以及决定新鲜冰冻血浆对每只犬的治疗方案是否有益及使用剂量的指导工具。
TEG可应用于治疗环境，作为为患有低凝状态的危重病犬量身定制个体化输血治疗的一种手段。
