Department of Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
Department of Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
J Therm Biol. 2019 Jul;83:54-59. doi: 10.1016/j.jtherbio.2019.05.006. Epub 2019 May 11.
The aim of this study was to examine the effect of estradiol (E) on the thermoregulatory responses induced by cinnamaldehyde, a component extracted from cinnamon at 16 °C or 27 °C. The thermoneutral and subneutral experiments were performed to evaluate the augmented effect of cinnamaldehyde by cold exposure and the effect of cinnamaldehyde itself. Ovariectomized rats were implanted with a silastic tube with or without E (E(+) and E(-) groups), and data loggers into the peritoneal cavity. After the application of 30% cinnamaldehyde or vehicle into the skin of the whole trunk of rats, the rats were exposed to 16 °C or 27 °C for 2 h. Body temperature (T) and tail temperature (T) were measured using a data logger and thermography. After exposure, blood samples were obtained, and plasma catecholamine concentration were measured by high-performance liquid chromatography. In the E(-) group exposed to 27 °C, the change in T in rats applied cinnamaldehyde was significantly lower than that of rats applied vehicle. The change in T in rats applied cinnamaldehyde was significantly lower than that of rats applied vehicle in both E(-) and E(+) groups at 27 °C and 16 °C. Plasma catecholamine concentration at 27 °C was not different among the groups. E might not affect thermoregulatory responses induced by cinnamaldehyde application; however, it decreased T in female rats.
本研究旨在探讨雌二醇（E）对肉桂醛诱导的热调节反应的影响，肉桂醛是从肉桂中提取的一种成分，在 16°C 或 27°C 下使用。进行了常温及亚常温实验，以评估冷暴露对肉桂醛增强作用的影响，以及肉桂醛本身的作用。将去卵巢大鼠用硅橡胶管植入 E（E(+) 和 E(-) 组），并将数据记录器植入腹腔。在大鼠整个躯干皮肤涂抹 30%肉桂醛或对照剂后，将大鼠暴露于 16°C 或 27°C 2 小时。使用数据记录器和热成像仪测量体温（T）和尾巴温度（T）。暴露后，采集血液样本，通过高效液相色谱法测量血浆儿茶酚胺浓度。在暴露于 27°C 的 E(-) 组中，应用肉桂醛的大鼠 T 的变化明显低于应用对照剂的大鼠。在 27°C 和 16°C 下，E(-) 和 E(+) 组中应用肉桂醛的大鼠 T 的变化均明显低于应用对照剂的大鼠。27°C 时各组血浆儿茶酚胺浓度无差异。E 可能不会影响肉桂醛应用引起的热调节反应；然而，它降低了雌性大鼠的 T。
