以植物为基础的明确饮食作为心力衰竭治疗的一种潜在治疗方法：临床病例系列。

A defined, plant-based diet as a potential therapeutic approach in the treatment of heart failure: A clinical case series.

机构信息

Department of Nutrition, Georgia State University, Atlanta, Georgia.

Houston Cardiac Association, Houston, Texas, United States; University of Texas Health Science Center, Houston, Texas, United States.

出版信息

Complement Ther Med. 2019 Aug;45:211-214. doi: 10.1016/j.ctim.2019.06.010. Epub 2019 Jun 29.

DOI:10.1016/j.ctim.2019.06.010

PMID:31331563

Abstract

BACKGROUND

Individuals diagnosed with congestive heart failure (CHF) have a 50% five-year mortality rate and approximately 650,000 new cases of CHF are diagnosed annually. Plant-based diets are known to improve plasma lipid concentrations, reduce blood pressure, and as part of a lifestyle intervention, lead to the regression of atherosclerotic lesions. However, a paucity of data exists with regards to plant-based diets in the treatment of CHF.

METHODS

Three patients diagnosed with CHF opted to undergo a dietary intervention consisting of a defined plant-based diet as an adjunct to standard medical treatment for CHF. Cardiac magnetic resonance imaging was performed. Patients' consumed the defined plant-based diet for an average of ˜79 days.

RESULTS

Follow-up cardiac magnetic resonance images revealed a 92% increase in ejection fraction [mean ± standard deviation for all data] (22.0 ± 6.9% vs 42.2 ± 18.4%), 21% reduction in left ventricular mass (214 ± 90 g vs 170 ± 102 g), 62% increase in stroke volume (55.8 ± 24.3 cc vs 90.3 ± 30.6 cc) and a 17% increase in cardiac output (3.6 ± 1.2 L/min vs 4.2 ± 1.6 L/min). In patient 1, 90-95% ostial stenosis of the left anterior descending artery nearly completely regressed following the dietary intervention. All patients subjectively reported significant clinical improvements, including less angina, shortness of breath and fatigue.

CONCLUSION

As an adjunct treatment, a defined plant-based diet may contribute to the reversal of cardiac morphological and functional abnormalities in the setting of CHF.

摘要

背景

充血性心力衰竭（CHF）患者的五年死亡率为 50%，每年约有 65 万例新的 CHF 病例被诊断。众所周知，植物性饮食可以改善血浆脂质浓度、降低血压，并且作为生活方式干预的一部分，可以使动脉粥样硬化病变消退。然而，关于植物性饮食在 CHF 治疗中的应用，数据仍然很少。

方法

三名被诊断为 CHF 的患者选择进行饮食干预，即采用一种特定的植物性饮食，作为 CHF 标准治疗的辅助手段。进行心脏磁共振成像检查。患者平均食用特定的植物性饮食约 79 天。

结果

随访心脏磁共振图像显示射血分数增加了 92%[所有数据的平均值±标准差]（22.0±6.9%比 42.2±18.4%），左心室质量减少了 21%（214±90 g 比 170±102 g），每搏量增加了 62%（55.8±24.3 cc 比 90.3±30.6 cc），心输出量增加了 17%（3.6±1.2 L/min 比 4.2±1.6 L/min）。在患者 1 中，左前降支近段 90-95%的开口狭窄在饮食干预后几乎完全消退。所有患者均报告主观上有明显的临床改善，包括心绞痛减轻、呼吸困难和疲劳减轻。