Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada, 89191, USA.
Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada, 89191, USA.
Complement Ther Med. 2019 Aug;45:85-88. doi: 10.1016/j.ctim.2019.05.022. Epub 2019 May 22.
To ensure that 16 weeks of methylsulfonylmethane (MSM) does not cause adverse effects in patients with the musculoskeletal disorders of osteoarthritis and back pain.
We carried out a subgroup analysis on data from a randomized, double-blind, placebo-controlled trial, "The use of Methylsulfonylmethane (MSM) in the treatment of low back pain," to determine the safety of taking 6 g daily of MSM (OptiMSM®, Bergstrom Nutrition). We monitored metabolic parameters to determine whether MSM altered hematologic, liver or kidney function. We also monitored physiologic parameters of blood pressure and weight.
Family Medicine Residency, Mike O'Callaghan Military Medical Center.
Metabolic parameters as measured by hematologic function - white blood cells (WBC), platelets, hemoglobin (Hb), glucose; liver function as measured by - total bilirubin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Physiologic parameters as measured by weight, diastolic (DBP) and systolic blood pressure (SBP); kidney function as measured by creatinine.
Analysis of outcome measures showed no significant difference between MSM and placebo (p < 0.05) safety values.
MSM has no effects on WBC, platelets, Hb, total bilirubin, AST, ALT, creatinine weight, DBP, or SBP in this study.
确保为期 16 周的甲磺酰甲烷（MSM）不会对骨关节炎和背痛等肌肉骨骼疾病患者产生不良反应。
我们对一项随机、双盲、安慰剂对照试验“甲磺酰甲烷（MSM）治疗腰痛的应用”的数据进行了亚组分析，以确定每天服用 6 克 MSM（OptiMSM®，Bergstrom Nutrition）的安全性。我们监测代谢参数以确定 MSM 是否改变了血液学、肝脏或肾脏功能。我们还监测了血压和体重等生理参数。
家庭医学住院医师培训计划，Mike O'Callaghan 军事医疗中心。
通过血液学功能（白细胞（WBC）、血小板、血红蛋白（Hb）、葡萄糖）测量的代谢参数；通过总胆红素、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）测量的肝功能；通过体重、舒张压（DBP）和收缩压（SBP）测量的生理参数；通过肌酐测量的肾功能。
对结果测量指标的分析表明，MSM 与安慰剂之间（p<0.05）无安全性差异。
在这项研究中，MSM 对 WBC、血小板、Hb、总胆红素、AST、ALT、肌酐、体重、DBP 或 SBP 没有影响。
