军事人员创伤性脑损伤的神经影像学：概述。
Neuroimaging of traumatic brain injury in military personnel: An overview.
机构信息
USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue, SHN, Los Angeles, CA 90033, USA.
Ethel Percy Andrus Gerontology Center, USC Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave., Room 228C, Los Angeles, CA 90089-0191, USA.
出版信息
J Clin Neurosci. 2019 Dec;70:1-10. doi: 10.1016/j.jocn.2019.07.001. Epub 2019 Jul 19.
BACKGROUND
The incidence of blunt-force traumatic brain injury (TBI) is especially prevalent in the military, where the emergency care admission rate has been reported to be 24.6-41.8 per 10,000 soldier-years. Given substantial advancements in modern neuroimaging techniques over the past decade in terms of structural, functional, and connectomic approaches, this mode of exploration can be viewed as best suited for understanding the underlying pathology and for providing proper intervention at effective time-points.
APPROACH
Here we survey neuroimaging studies of mild-to-severe TBI in military veterans with the intent to aid the field in the creation of a roadmap for clinicians and researchers whose aim is to understand TBI progression.
DISCUSSION
Recent advancements on the quantification of neurocognitive dysfunction, cellular dysfunction, intracranial pressure, cerebral blood flow, inflammation, post-traumatic neuropathophysiology, on blood serum biomarkers and on their correlation to neuroimaging findings are reviewed to hypothesize how they can be used in conjunction with one another. This may allow clinicians and scientists to comprehensively study TBI in military service members, leading to new treatment strategies for both currently-serving as well as veteran personnel, and to improve the study of TBI more broadly.
背景
钝器性创伤性脑损伤（TBI）的发病率在军队中尤为普遍，据报道，其急诊入院率为每 10000 名士兵年 24.6-41.8 例。鉴于过去十年中现代神经影像学技术在结构、功能和连接组学方法方面取得了实质性进展，这种探索模式可被视为最适合了解潜在病理并在有效时间点提供适当干预的方法。
方法
在这里，我们调查了患有轻度至重度创伤性脑损伤的退伍军人的神经影像学研究，旨在为临床医生和研究人员创建一个路线图，帮助他们了解创伤性脑损伤的进展。
讨论
最近在神经认知功能障碍、细胞功能障碍、颅内压、脑血流、炎症、创伤后神经病理学、血清生物标志物及其与神经影像学发现的相关性的定量方面的进展进行了综述，以假设它们如何可以相互结合使用。这可能使临床医生和科学家能够全面研究军队服役人员的 TBI，为现役和退伍军人制定新的治疗策略，并更广泛地改善 TBI 的研究。
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