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一种源自人类的探针p82H与大猩猩、黑猩猩和猩猩的着丝粒杂交。

A human-derived probe, p82H, hybridizes to the centromeres of gorilla, chimpanzee, and orangutan.

作者信息

Miller D A, Sharma V, Mitchell A R

机构信息

Department of Molecular Biology and Genetics, Wayne State University, Detroit, MI 48201.

出版信息

Chromosoma. 1988;96(4):270-4. doi: 10.1007/BF00286913.

DOI:10.1007/BF00286913
PMID:3133178
Abstract

A human-derived centromeric sequence, p82H, hybridizes to DNA from gorilla, chimpanzee, pygmy chimpanzee, and orangutan. On DNA blots, multimeric ladders based on 170 or 340 bp repeat units are seen. In metaphase chromosome preparations from these species, p82H hybridizes to the centromeric region of every chromosome. p82H forms less stable hybrids with DNA from the lion-tailed macaque and does not hybridize to DNA or chromosomes of the owl monkey or the mouse.

摘要

一种人类来源的着丝粒序列p82H，能与大猩猩、黑猩猩、倭黑猩猩和猩猩的DNA杂交。在DNA印迹上，可以看到基于170或340 bp重复单元的多聚体梯状条带。在这些物种的中期染色体标本中，p82H与每条染色体的着丝粒区域杂交。p82H与狮尾猕猴的DNA形成的杂交体稳定性较差，且不与夜猴或小鼠的DNA或染色体杂交。

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