Department of Orthopedics, the Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Department of Bone and Joint Rehabilitation, Yunnan Province Disabled Rehabilitation Center, Kunming, China.
Eur Spine J. 2019 Sep;28(9):2012-2019. doi: 10.1007/s00586-019-06075-1. Epub 2019 Jul 22.
A meta-analysis was conducted to compare the efficacy and safety of bracing and other treatments in adolescent idiopathic scoliosis (AIS) patients.
PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched for randomized controlled trials that investigated bracing and other treatments for AIS. The Mantel-Haenszel method with fixed-effects or random-effects model was used to calculate the relative risks and 95% confidence intervals (CIs). The results of heterogeneity, sensitivity analysis, and publication bias were analyzed.
Seven studies that met the eligibility criteria with 791 participants were included. The results of meta-analysis suggested significant differences between bracing and observation groups in successful outcomes [OR 3.58, 95% CI (1.92, 6.68), P < 0.0001; P for heterogeneity = 0.008, I = 65%], quality of life [MD = 2.13, 95% CI (0.51, 3.75), P = 0.01; P for heterogeneity = 0.89, I = 0%], and adverse events [OR 5.31, 95% CI (2.42, 11.66), P < 0.0001; P for heterogeneity = 0.78, I = 0%].
The findings of this meta-analysis suggested that bracing is efficient and safe for the treatment of AIS. These slides can be retrieved under Electronic Supplementary Material.
进行荟萃分析以比较支具和其他治疗方法在青少年特发性脊柱侧凸（AIS）患者中的疗效和安全性。
检索 PubMed、Embase 和 Cochrane 对照试验中心注册库，以寻找评估支具和其他治疗 AIS 方法的随机对照试验。采用固定效应或随机效应模型的 Mantel-Haenszel 方法计算相对风险和 95%置信区间（CI）。分析异质性、敏感性分析和发表偏倚的结果。
纳入了 7 项符合入选标准的研究，共 791 名参与者。荟萃分析结果表明，支具组与观察组在治疗结果[OR 3.58，95%CI（1.92，6.68），P<0.0001；P 异质性=0.008，I=65%]、生活质量[MD=2.13，95%CI（0.51，3.75），P=0.01；P 异质性=0.89，I=0%]和不良事件[OR 5.31，95%CI（2.42，11.66），P<0.0001；P 异质性=0.78，I=0%]方面存在显著差异。
这项荟萃分析的结果表明，支具治疗 AIS 既有效又安全。这些幻灯片可以在电子补充材料中检索到。
