内源性大麻素系统在发育过程中的生理学。

Physiology of the Endocannabinoid System During Development.

机构信息

Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.

出版信息

Adv Exp Med Biol. 2019;1162:13-37. doi: 10.1007/978-3-030-21737-2_2.

Abstract

The endocannabinoid (eCB) system comprises endogenously produced cannabinoids (CBs), enzymes of their production and degradation, and CB-sensing receptors and transporters. The eCB system plays a critical role in virtually all stages of animal development. Studies on eCB system components and their physiological role have gained increasing attention with the rising legalization and medical use of marijuana products. The latter represent exogenous interventions that target the eCB system. This chapter summarizes knowledge in the field of CB contribution to gametogenesis, fertilization, embryo implantation, fetal development, birth, and adolescence-equivalent periods of ontogenesis. The material is complemented by the overview of data from our laboratory documenting the functional presence of the eCB system within cerebral arteries of baboons at different stages of development.

摘要

内源性大麻素（eCB）系统包括内源性大麻素（CBs）、其产生和降解的酶，以及 CB 感应受体和转运体。eCB 系统在动物发育的几乎所有阶段都起着至关重要的作用。随着大麻产品合法化和医疗用途的增加，对 eCB 系统成分及其生理作用的研究越来越受到关注。后者代表了针对 eCB 系统的外源性干预。本章总结了 CB 对配子发生、受精、胚胎着床、胎儿发育、出生和青春期等发育阶段的贡献方面的知识。此外，还概述了我们实验室的数据，这些数据记录了在不同发育阶段的狒狒大脑动脉中 eCB 系统的功能存在。