Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Rev Physiol Biochem Pharmacol. 2023;184:1-31. doi: 10.1007/112_2021_64.
The existence of a formal Endocannabinoid System in C. elegans has been questioned due to data showing the absence of typical cannabinoid receptors in the worm; however, the presence of a full metabolism for endocannabinoids, alternative ligands, and receptors for these agents and a considerable number of orthologous and homologous genes regulating physiological cannabinoid-like signals and responses - several of which are similar to those of mammals - demonstrates a well-structured and functional complex system in nematodes. In this review, we describe and compare similarities and differences between the Endocannabinoid System in mammals and nematodes, highlighting the basis for the integral study of this novel system in the worm.
由于数据显示线虫中不存在典型的大麻素受体，因此线虫中存在正式的内源性大麻素系统一直受到质疑；然而，内源性大麻素的完整代谢、替代配体以及这些药物的受体，以及调节生理类似大麻素信号和反应的大量同源和同系基因 - 其中一些与哺乳动物相似 - 证明了线虫中存在一个结构良好且功能复杂的系统。在这篇综述中，我们描述并比较了哺乳动物和线虫中内源性大麻素系统的相似之处和不同之处，强调了在蠕虫中对这个新系统进行综合研究的基础。
