Circulatory Physiology Department, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine.
Adv Exp Med Biol. 2019;1162:63-87. doi: 10.1007/978-3-030-21737-2_5.
Cannabinoids influence cardiovascular variables in health and disease via multiple mechanisms. The chapter covers the impact of cannabinoids on cardiovascular function in physiology and pathology and presents a critical analysis of the proposed signalling pathways governing regulation of cardiovascular function by endogenously produced and exogenous cannabinoids. We know that endocannabinoid system is overactivated under pathological conditions and plays both a protective compensatory role, such as in some forms of hypertension, atherosclerosis and other inflammatory conditions, and a pathophysiological role, such as in disease states associated with excessive hypotension. This chapter focuses on the mechanisms affecting hemodynamics and vasomotor effects of cannabinoids in health and disease states, highlighting mismatches between some studies. The chapter will first review the effects of marijuana smoking on cardiovascular system and then describe the impact of exogenous cannabinoids on cardiovascular parameters in humans and experimental animals. This will be followed by analysis of the impact of cannabinoids on reactivity of isolated vessels. The article critically reviews current knowledge on cannabinoid induction of vascular relaxation by cannabinoid receptor-dependent and -independent mechanisms and dysregulation of vascular endocannabinoid signaling in disease states.
大麻素通过多种机制影响心血管变量在健康和疾病。本章涵盖了大麻素对心血管功能在生理学和病理学中的影响，并对拟议的信号通路进行了批判性分析，这些信号通路控制内源性和外源性大麻素对心血管功能的调节。我们知道，在病理条件下，内源性大麻素系统过度激活，发挥保护代偿作用，如在某些形式的高血压、动脉粥样硬化和其他炎症状态下，以及发挥病理生理作用，如与过度低血压相关的疾病状态下。本章重点介绍影响大麻素在健康和疾病状态下对血液动力学和血管舒缩作用的机制，强调了一些研究之间的不匹配。本章首先回顾了吸烟对心血管系统的影响，然后描述了外源性大麻素对人类和实验动物心血管参数的影响。接下来，分析了大麻素对分离血管反应性的影响。本文批判性地回顾了当前关于大麻素通过大麻素受体依赖性和非依赖性机制诱导血管舒张以及在疾病状态下血管内源性大麻素信号转导失调的知识。
