Department of Criminology and Forensic Science, School of Applied Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, India.
Department of Zoology, School of Life Science, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, India.
J Biochem Mol Toxicol. 2019 Sep;33(9):e22367. doi: 10.1002/jbt.22367. Epub 2019 Jul 23.
The present study investigated the pesticide induced adverse health effects, hematological and biochemical alterations among agriculture workers. A cross sectional study of 51 agriculture workers and 54 unexposed subjects was carried out to evaluate hematological and biochemical alterations in blood. Pesticide exposed individuals were reported adverse clinical outcomes, including tingling, muscle pain, headache, skin disease, etc. A significant alterations in the level of hematological parameters, liver and renal dysfunctions markers and lipid profile suggested hematological, hepatic and renal dysfunctions. A significant decrease in the activity of acetylcholinesterase, reduced glutathione, superoxide dismutase, catalase and increased level of lipid peroxidation was also observed in these agriculture workers. Correlation coefficient analysis showed a positive correlation of chronic exposure with most of the hematological and biochemical parameters. The results demonstrate that the chronic exposure of pesticides cause reduction in the acetylcholinesterase activity and enhanced the risk of adverse clinical outcomes in agriculture workers.
本研究调查了农药对农业工人的不良健康影响、血液学和生物化学改变。进行了一项 51 名农业工人和 54 名未暴露于农药的对照者的横断面研究，以评估血液学和生物化学改变。接触农药的个体报告了不良的临床结果，包括刺痛、肌肉疼痛、头痛、皮肤病等。血液学参数、肝肾功能标志物和脂质谱水平的显著改变提示存在血液学、肝和肾功能障碍。还观察到这些农业工人乙酰胆碱酯酶活性、谷胱甘肽、超氧化物歧化酶、过氧化氢酶活性降低，脂质过氧化水平升高。相关系数分析显示，慢性暴露与大多数血液学和生物化学参数呈正相关。结果表明，农药的慢性暴露导致乙酰胆碱酯酶活性降低，并增加了农业工人发生不良临床结果的风险。
