Department of Genetic Biochemistry, Faculty of Biotechnology, Wroclaw University, Wroclaw, Poland.
Curr Pharm Des. 2019;25(20):2241-2263. doi: 10.2174/1381612825666190716111700.
The incidence of inflammatory skin diseases is increasing, so the search for relevant therapeutics is of major concern. Plants are rich in phytochemicals which can alleviate many symptoms. In this review, we concentrate on compounds found in the seeds of widely cultivated plants, regularly used for oil production. The oils from these plants are often used to alleviate the symptoms of inflammatory diseases through synergetic action of unsaturated fatty acids and other phytochemicals most commonly derived from the terpenoid pathway. The knowledge of the chemical composition of oil seeds and the understanding of the mechanisms of action of single components should allow for a more tailored approach for the treatment for many diseases. In many cases, these seeds could serve as an efficient material for the isolation of pure phytochemicals. Here we present the content of phytochemicals, assumed to be responsible for healing properties of plant oils in a widely cultivated oil seed plants and review the proposed mechanism of action for fatty acids, selected mono-, sesqui-, di- and triterpenes, carotenoids, tocopherol and polyphenols.
炎症性皮肤病的发病率不断上升，因此寻找相关治疗方法是当务之急。植物富含植物化学物质，可以缓解许多症状。在这篇综述中，我们集中研究了广泛种植的、常用于生产油的植物种子中发现的化合物。这些植物的油通常通过不饱和脂肪酸和其他植物化学物质的协同作用来缓解炎症性疾病的症状，这些植物化学物质最常见于萜类途径中衍生而来。对油籽化学成分的了解和对单一成分作用机制的理解，应该可以为治疗许多疾病提供更有针对性的方法。在许多情况下，这些种子可以作为分离纯植物化学物质的有效材料。在这里，我们介绍了在广泛种植的油籽植物中，被认为对植物油脂具有愈合作用的植物化学物质的含量，并综述了脂肪酸、选择的单萜、倍半萜、二萜和三萜、类胡萝卜素、生育酚和多酚的作用机制。
