School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, India.
Curr Pharm Des. 2019;25(23):2569-2583. doi: 10.2174/1381612825666190716125332.
Diabetes has turned out to be one of the biggest worldwide health and economic burdens, with its expanded predominance and high complexity proportion. The quantity of diabetic patients is expanding enormously around the world. Several reports have demonstrated the sharp increment in the sufferers. Stable and acceptable blood glucose control is fundamental to diminish diabetes-related complications. Consequently, ceaseless endeavors have been made in antidiabetic drugs, treatment strategies, and nanotechnology based products to accomplish better diabetes control. The nanocarriers pertaining hypoglycaemics provide improved diabetes management with minimum risk of associated side effects. Dendrimers have caught an incredible attention in the field of drug delivery and personalized medicines. Dendrimers are three-dimensional well-defined homogenous nanosized structures consisting tree-like branches. The present review highlights the different aspects of dendrimers including fabrication, surface engineering, toxicological profile as well as delivery of antidiabetic drugs for the effective cure of diabetes.
糖尿病已成为全球最大的健康和经济负担之一，其发病率不断上升且复杂程度高。全球范围内糖尿病患者数量正在大幅增加。有几项报告表明患者数量急剧增加。稳定和可接受的血糖控制对于减少糖尿病相关并发症至关重要。因此，人们一直在努力开发抗糖尿病药物、治疗策略和基于纳米技术的产品，以实现更好的糖尿病控制。低血糖纳米载体提供了改善的糖尿病管理，同时最小化了相关副作用的风险。树状聚合物在药物输送和个性化药物领域引起了广泛关注。树状聚合物是一种具有三维结构、明确的、均一的纳米级结构，由树枝状分支组成。本综述重点介绍了树状聚合物的不同方面，包括其制备、表面工程、毒理学特性以及抗糖尿病药物的传递，以有效治疗糖尿病。
