Ficek Krzysztof, Ciȩszczyk Paweł, Leźnicka Katarzyna, Kaczmarczyk Mariusz, Leońska-Duniec Agata
Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland.
Front Physiol. 2019 Jul 5;10:876. doi: 10.3389/fphys.2019.00876. eCollection 2019.
Based on the important role of interleukin-15 (IL-15) in human metabolism and, in consequence, in body composition modulation, we examined whether rs1589241 and rs1057972 polymorphisms, analyzed individually or in combination, would influence the effects of a training program. Accordingly, we studied the allele and genotype distribution in a group of 163 young nonobese Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the completion of a 12-week endurance training program. After a week-long familiarization stage, low-high impact aerobics were conducted three times a week for 60 min, at an increasing intensity from about 50 to 80% of HRmax. With reference to rs1057972 genotypes, there were two significant genotype × training interactions, in which (i) fat mass percentage (FM%) significantly decreased among the AA homozygotes ( = 0.00002) and AT heterozygotes ( = 0.00002), and (ii) fat free mass (FFM) increased only among the AT heterozygotes ( = 0.0003), whereas in the AA homozygotes there was only a borderline significance ( = 0.065). No genotype × training interactions were found for the second rs1589241 polymorphism. Moreover, the carriers of the[T;A] haplotype (when compared with reference haplotype) displayed significant decrease in FM% ( = 0.027) and increase in FFM ( = 0.014) in response to the applied training program. Our data highlight novel associations between specific genotype and different post-training changes of FM% and FFM parameters. The results suggest that harboring the rs1057972 A allele and/or the [T;A] haplotype is favorable for achieving specific positive training-induced body composition changes.
基于白细胞介素-15（IL-15）在人体新陈代谢以及由此在身体成分调节中的重要作用，我们研究了rs1589241和rs1057972多态性单独或联合分析时是否会影响训练计划的效果。因此，我们研究了163名年轻非肥胖白种女性群体中的等位基因和基因型分布，这些女性在完成为期12周的耐力训练计划前后测量了选定的体重和身体成分以及生化参数。在为期一周的适应阶段后，每周进行三次60分钟的低-高冲击有氧运动，强度从约50%HRmax逐渐增加到80%HRmax。关于rs1057972基因型，有两个显著的基因型×训练交互作用，其中（i）AA纯合子（P = 0.00002）和AT杂合子（P = 0.00002）的脂肪质量百分比（FM%）显著降低，（ii）仅AT杂合子的去脂体重（FFM）增加（P = 0.0003），而AA纯合子仅有临界显著性（P = 0.065）。对于第二个rs1589241多态性未发现基因型×训练交互作用。此外，[T;A]单倍型携带者（与参考单倍型相比）在应用训练计划后，FM%显著降低（P = 0.027），FFM增加（P = 0.014）。我们的数据突出了特定基因型与FM%和FFM参数不同的训练后变化之间的新关联。结果表明，携带rs1057972 A等位基因和/或[T;A]单倍型有利于实现训练诱导的特定积极身体成分变化。
