Mo Yongzhen, Wang Yumin, Zhang Lishen, Yang Liting, Zhou Ming, Li Xiaoling, Li Yong, Li Guiyuan, Zeng Zhaoyang, Xiong Wei, Xiong Fang, Guo Can
NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha 410078, China.
J Cancer. 2019 Jun 9;10(16):3789-3797. doi: 10.7150/jca.31166. eCollection 2019.
The occurrence and development of tumors is a complex process involving long-term multi-factor participation. In this process, tumor cells from a set of abnormal metabolic patterns that are different from normal cells. This abnormal metabolic change is called metabolic reprogramming of tumors. Wnt signaling pathway is one of the critical signaling pathways regulating cell proliferation and differentiation. In recent years, it has been found that Wnt signaling participates in the occurrence and development of malignant tumors by affecting metabolic reprogramming. This paper reviews the role of Wnt signaling in tumor metabolic reprogramming to provide crucial theoretical guidance for targeted therapy and drug response of tumors.
肿瘤的发生发展是一个涉及长期多因素参与的复杂过程。在此过程中，肿瘤细胞形成了一套与正常细胞不同的异常代谢模式。这种异常的代谢变化被称为肿瘤的代谢重编程。Wnt信号通路是调节细胞增殖和分化的关键信号通路之一。近年来，研究发现Wnt信号通路通过影响代谢重编程参与恶性肿瘤的发生发展。本文综述Wnt信号在肿瘤代谢重编程中的作用，为肿瘤的靶向治疗和药物反应提供重要的理论指导。
