揭示皮肤黑色素瘤信号通路的异质性：对预后价值和免疫相互作用的见解
Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions.
作者信息
Liu Yufang, Li Chunyan, Deng Weiwei
机构信息
Department of Dermatology and Venereology, Fuyang People's Hospital, Fuyang, Anhui, 236000, People's Republic of China.
Department of Dermatology and Venereology, Dermatology Hospital of Southern Medical University, Department of Dermatology, Guangzhou, People's Republic of China.
出版信息
Clin Cosmet Investig Dermatol. 2025 Jan 8;18:47-59. doi: 10.2147/CCID.S500654. eCollection 2025.
BACKGROUND
Signaling pathways play crucial roles in tumor cells. However, functional heterogeneity of signaling pathways in skin cutaneous melanoma (SKCM) has not been established.
METHODS
Based on a recent computational pipeline, pathway activities between SKCM and normal samples were identified.
RESULTS
The results showed that high activities in 12 pathways were associated with poor prognoses, while high activities in 17 pathways were associated with favorable prognoses. Interestingly, elevated metabolic pathway activity was unfavorable, whereas elevated immune activity was favorable for SKCM. Unfavorably elevated metabolic pathways strongly correlated with Wnt/beta-catenin signaling. Conversely, favorable pathways, such as glycosaminoglycan biosynthesis and keratan sulfate, were strongly correlated with anti-tumor pathways. Moreover, the activities of favorable pathways were strongly positively correlated with infiltrating CD8 T cells, macrophages M1, immune score, and stromal score, all of which were favorable for SKCM.
CONCLUSION
Taken together, our study provides insights into the characteristics of several pathways in SKCM.
背景
信号通路在肿瘤细胞中起着至关重要的作用。然而，皮肤黑色素瘤（SKCM）中信号通路的功能异质性尚未明确。
方法
基于最近的计算流程，确定了SKCM与正常样本之间的通路活性。
结果
结果显示，12条通路的高活性与预后不良相关，而17条通路的高活性与预后良好相关。有趣的是，代谢通路活性升高对SKCM不利，而免疫活性升高则对SKCM有利。代谢通路的不利升高与Wnt/β-连环蛋白信号传导密切相关。相反，有利的通路，如糖胺聚糖生物合成和硫酸角质素，与抗肿瘤通路密切相关。此外，有利通路的活性与浸润性CD8 T细胞、M1巨噬细胞、免疫评分和基质评分呈强正相关，所有这些都对SKCM有利。
结论
综上所述，我们的研究为SKCM中几种通路的特征提供了见解。
Zotero 插件