Litoriya Anu, Tiwari Uma Saran, Pathak Rachna
Department of Ophthalmology, Gajra Raja Medical College, Gwalior, India.
Rom J Ophthalmol. 2019 Apr-Jun;63(2):142-145.
To quantitatively evaluate the cardiopulmonary effects of various topical antiglaucoma drugs. In this study, forty consecutive cases of newly diagnosed primary open angle glaucoma were recruited. After taking a detailed history, an ophthalmological examination and a systemic examination including resting pulse rate, blood pressure, ECG, auscultation of the chest and spirometry were performed. Then the patients were randomly divided into four groups and one of the four topical anti glaucoma medication (Timolol, Latanoprost, Brimonidine, and Dorzolamide) prescribed. Patients were reviewed 4 weeks later and the same ocular and systemic examinations were performed. Timolol therapy reduced all the spirometry parameters that are statistically significant difference with the P value of less than 0.1. Timolol therapy resulted in the mean reduction of pulse rate by 3.2 beats/ minute and a mean reduction of systolic and diastolic blood pressure by 5.8 mmHg and 5.6 mmHg, respectively all the spirometry & cardiovascular parameters remained unchanged in the other three groups after 4 weeks of treatment. Timolol significantly affects the cardiopulmonary status. Therefore, we could advice the assessment of cardiopulmonary status mandatory in patients receiving topical beta-blockers. Bronchospasm may be of clinical significance in the elderly, who commonly have undiagnosed reversible airway obstruction.
为定量评估各种局部抗青光眼药物对心肺的影响。在本研究中，连续招募了40例新诊断的原发性开角型青光眼患者。详细询问病史后，进行眼科检查以及包括静息脉搏率、血压、心电图、胸部听诊和肺活量测定在内的全身检查。然后将患者随机分为四组，并开具四种局部抗青光眼药物（噻吗洛尔、拉坦前列素、溴莫尼定和多佐胺）中的一种。4周后对患者进行复查，并进行相同的眼部和全身检查。噻吗洛尔治疗使所有肺活量测定参数降低，P值小于0.1，差异具有统计学意义。噻吗洛尔治疗使脉搏率平均降低3.2次/分钟，收缩压和舒张压分别平均降低5.8 mmHg和5.6 mmHg。治疗4周后，其他三组的所有肺活量测定和心血管参数均保持不变。噻吗洛尔显著影响心肺状态。因此，我们建议对接受局部β受体阻滞剂治疗的患者进行心肺状态评估。支气管痉挛在老年人中可能具有临床意义，因为他们通常患有未被诊断的可逆性气道阻塞。
