中国一家三级医院中 ST290 的爆发。
Outbreak of -Harboring ST290 in a Tertiary Hospital in China.
机构信息
Department of Clinical Laboratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Emergency Intensive Care Unit, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
Microb Drug Resist. 2019 Dec;25(10):1443-1448. doi: 10.1089/mdr.2019.0046. Epub 2019 Jul 22.
The emergence of carbapenem-resistant (CRKP) has posed a great threat to public health. Among 133 nonduplicated CRKP isolates collected between September 2016 and November 2017 in a tertiary hospital in China, 89 (89/133, 66.9%) and 31 (31/133, 23.3%) were positive for and . Multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) revealed that ST290 represented the majority of NDM-5 producers (67/89, 75.3%) and PFGE cluster E accounted for 50 (50/67, 74.6%) ST290 isolates from the burn ward, suggesting that ST290 clone carrying resulted in an outbreak in this hospital. Whole genome sequencing of the plasmid carrying showed that the resistance gene was located in a ∼49 kb multireplicon plasmid with a peculiar insertion of IS of the IncX3-type plasmid. To the best of our knowledge, this is the first report of outbreak of ST290 clone carrying .
碳青霉烯类耐药肠杆菌科细菌（CRKP）的出现对公共健康构成了巨大威胁。在中国一家三级医院于 2016 年 9 月至 2017 年 11 月期间收集的 133 例非重复 CRKP 分离株中，89 株（89/133，66.9%）和 31 株（31/133，23.3%）携带blaNDM-5 和blaCTX-M-15。多位点序列分型（MLST）和脉冲场凝胶电泳（PFGE）显示，ST290 代表了大多数 NDM-5 产生者（67/89，75.3%），PFGE 簇 E 占烧伤病房 50 株 ST290 分离株（50/67，74.6%），表明携带 blaNDM-5 的 ST290 克隆导致了该医院的暴发。携带 blaNDM-5 的质粒的全基因组测序显示，耐药基因 blaNDM-5 位于一个约 49kb 的多复制子质粒中，该质粒具有 IncX3 型质粒的独特插入的 IS。据我们所知，这是首次报道携带 blaNDM-5 的 ST290 克隆的暴发。
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