Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology , Technical University of Denmark , 2800 Kongens Lyngby , Denmark.
Department of Electrical Engineering and Information Technology , University of Naples Federico II , 80138 Naples , Italy.
Anal Chem. 2019 Sep 17;91(18):11620-11628. doi: 10.1021/acs.analchem.9b02026. Epub 2019 Aug 6.
Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.
在碟式实验室（LoD）系统中将电化学传感器与电化学工作站接口连接通常是繁琐且具有挑战性的。在这里，我们提出了第一个用于离心微流控应用的多通道、模块化、重量轻且无线供电的定制碟上电化学工作站（PoD）。所开发的电化学工作站采用典型的数字视频光盘（DVD）的外形尺寸，重量仅为 127 克。该电化学工作站的设计便于与 LoD 系统中的电极进行简单且稳固的接口连接，同时在旋转过程中实现实时电化学检测。该设备可以执行不同的电化学分析技术，如循环伏安法、方波伏安法和安培法，同时可以通过定制软件进行控制。使用自制和商业电极进行了有无旋转的测量。PoD 的性能与使用具有 200 pA 测量电流分辨率的商用电化学工作站获得的结果非常吻合。作为概念验证，我们从用于药物输送的微器件实时释放了一种电化学活性化合物。
